Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 11/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 12/20 | 0.49 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10678325 | 0.84 | NPC1 (0.59) | NPC1LMNADYRK1ARAB9AMAPT | |
| SCHEMBL11020618 | 0.80 | MAPT (0.67) | NPC1LMNADYRK1ARAB9AMAPT | |
| SCHEMBL17123531 | 0.80 | MAPT (0.67) | NPC1LMNADYRK1ARAB9AMAPT | |
| SCHEMBL24705959 | 0.77 | DYRK1A (0.53) | NPC1LMNADYRK1ARAB9AMAPT | |
| SCHEMBL13151088 | 0.77 | NPC1 (0.64) | NPC1LMNADYRK1ARAB9AMAPT | |
| SCHEMBL2115626 | 0.76 | NPC1 (0.65) | NPC1LMNADYRK1ARAB9AMAPT | |
| SCHEMBL21914837 | 0.76 | NPC1 (0.62) | NPC1LMNADYRK1ARAB9AMAPT | |
| SCHEMBL14189677 | 0.75 | NPC1 (0.57) | NPC1LMNADYRK1ARAB9AMAPT | |
| SCHEMBL14189675 | 0.75 | NPC1 (0.61) | NPC1LMNADYRK1ARAB9AMAPT | |
| SCHEMBL11019331 | 0.75 | IDO1 (0.59) | NPC1LMNADYRK1ARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4732986-A | Benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing these compounds | LUDWIG HEUMANN & CO. GMBH (DE) | 1988-03-22 | — | — | US | disclosed |
| EP-0160173-A1 | Benzothiazole derivatives, processes for their production and medicaments containing them | LUDWIG HEUMANN & CO GMBH (DE) | 1985-11-06 | — | — | EP | disclosed |