Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 15/20 | 0.67 |
| ▸ | NPC1 | O15118 | 14/20 | 0.67 |
| ▸ | RAB9A | P51151 | 14/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 12/20 | 0.67 |
| ▸ | GAA | P10253 | 11/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 12/20 | 0.61 |
| ▸ | MEN1 | O00255 | 11/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.61 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.61 |
| ▸ | RELA | Q04206 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | GLA | P06280 | 1/20 | 0.60 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17123531 | 1.00 | MAPT (0.67) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL11020602 | 0.83 | MAPT (0.79) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL8592761 | 0.82 | MAPT (0.61) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL8592758 | 0.82 | MAPT (0.61) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1231353 | 0.81 | MAPT (0.70) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL1231354 | 0.81 | MAPT (0.70) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL10672271 | 0.80 | NPC1 (0.55) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL10678325 | 0.78 | NPC1 (0.59) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL11019331 | 0.78 | IDO1 (0.59) | MAPTNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL22331496 | 0.77 | MAPT (0.59) | MAPTNPC1RAB9ASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0158083-A2 | Medicines | LUDWIG HEUMANN & CO GMBH (DE) | 1985-10-16 | — | — | EP | disclosed |