Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | GRIN1 | Q05586 | 8/20 | 0.53 |
| ▸ | GRIN2B | Q13224 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | KIF11 | P52732 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7907147 | 0.83 | KDM4E (0.58) | KDM4EGRIN1GRIN2BALDH1A1LMNA | |
| SCHEMBL9764795 | 0.82 | GRIN1 (0.58) | KDM4EGRIN1GRIN2BALDH1A1LMNA | |
| SCHEMBL8763454 | 0.78 | GRIN1 (0.65) | KDM4EGRIN1GRIN2BALDH1A1LMNA | |
| SCHEMBL8868256 | 0.78 | KDM4E (0.61) | KDM4EGRIN1GRIN2BALDH1A1LMNA | |
| SCHEMBL4149990 | 0.78 | HPGD (0.61) | KDM4EALDH1A1LMNAHPGDHTT | |
| SCHEMBL9258543 | 0.78 | KDM4E (0.61) | KDM4EGRIN1GRIN2BALDH1A1LMNA | |
| SCHEMBL5726108 | 0.77 | HPGD (0.57) | KDM4EGRIN1GRIN2BALDH1A1LMNA | |
| SCHEMBL657740 | 0.76 | ALDH1A1 (0.64) | KDM4EGRIN1GRIN2BALDH1A1LMNA | |
| SCHEMBL8763605 | 0.76 | KDM4E (0.59) | KDM4EGRIN1GRIN2BALDH1A1LMNA | |
| SCHEMBL10750177 | 0.76 | ALDH1A1 (0.59) | KDM4EGRIN1GRIN2BALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2488489-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc. (US) | 2012-08-22 | — | — | EP | disclosed |
| WO-2011045703-A2 | C-LINKED HYDROXAMIC ACID DERIVATIVES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2011-04-21 | — | — | WO | disclosed |