Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.53 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.53 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.53 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL657740 | 0.90 | ALDH1A1 (0.64) | KDM4EGRIN1GRIN2BALDH1A1SMN1; SMN2 | |
| SCHEMBL9764795 | 0.86 | GRIN1 (0.58) | KDM4EGRIN1GRIN2BALDH1A1SMN1; SMN2 | |
| SCHEMBL10673 | 0.83 | KDM4E (0.54) | KDM4EGRIN1GRIN2BALDH1A1SMN1; SMN2 | |
| SCHEMBL8763454 | 0.82 | GRIN1 (0.65) | KDM4EGRIN1GRIN2BALDH1A1SMN1; SMN2 | |
| SCHEMBL8868256 | 0.81 | KDM4E (0.61) | KDM4EGRIN1GRIN2BALDH1A1SMN1; SMN2 | |
| SCHEMBL5726108 | 0.81 | HPGD (0.57) | KDM4EGRIN1GRIN2BALDH1A1SMN1; SMN2 | |
| SCHEMBL5737290 | 0.81 | ALDH1A1 (0.56) | KDM4EGRIN1GRIN2BALDH1A1SMN1; SMN2 | |
| SCHEMBL2692935 | 0.80 | HDAC1 (0.78) | ALDH1A1SMN1; SMN2HDAC1HDAC8HDAC3 | |
| SCHEMBL10750177 | 0.80 | ALDH1A1 (0.59) | KDM4EGRIN1GRIN2BALDH1A1SMN1; SMN2 | |
| SCHEMBL9326251 | 0.80 | ALDH1A1 (0.85) | ALDH1A1LMNAHPGDHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104067122-B | Based on acridine and the fluorescent dye of acridine derivatives | 艾尔玛可科学（苏格兰）有限公司 | 2016-10-12 | — | — | CN | disclosed |
| CN-105492428-A | Methods and compositions for treating beta-thalassemia and sickle cell disease | ACADEMIA SINICA | 2016-04-13 | — | — | CN | disclosed |
| US-6197975-B1 | 7-AZABICYCLO(2.2.1)HEPTANE-7-CARBONYL-SUBSTITUTED 2-PHENYLINDOLE DERIVATIVES; SEXUAL DISORDERS; ANTICARCINOGENIC AGENTS | MERCK & CO. , INC. | 2001-03-06 | — | — | US | disclosed |
| EP-0868178-A4 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 2000-03-29 | — | — | EP | disclosed |
| EP-0882040-A4 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO INC (US) | 1999-02-10 | — | — | EP | disclosed |
| EP-0882040-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1998-12-09 | — | — | EP | disclosed |
| EP-0868178-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | Merck & Co., Inc. (US) | 1998-10-07 | — | — | EP | disclosed |
| US-5756507-A | TREATING SEX HORMONE RELATED DISORDERS | MERCK & CO., INC. (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0781273-A1 | 4-(4-METHANESULFONAMIDOPHENYL)BUTYLAMINE DERIVATIVES WITH ANTIARRHYTHMIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1997-07-02 | — | — | EP | disclosed |
| WO-1997021707-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | disclosed |
| WO-1997021435-A1 | ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE | MERCK & CO., INC. (US) | 1997-06-19 | — | — | WO | disclosed |
| WO-1996008471-A1 | 4-(4-METHANESULFONAMIDOPHENYL)BUTYLAMINE DERIVATIVES WITH ANTIARRHYTHMIC ACTIVITY | PHARMACIA & UPJOHN COMPANY (US) | 1996-03-21 | — | — | WO | disclosed |
| CN-1030409-A | Indole derivatives and preparation method thereof | GLAXO GROUP LTD (GB) | 1989-01-18 | — | — | CN | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |