Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chlorcyclizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 known ✓ | Q12809 | 5/20 | 0.97 |
| ▸ | CHRM2 known ✓ | P08172 | 4/20 | 0.97 |
| ▸ | ADRA2A known ✓ | P08913 | 4/20 | 0.97 |
| ▸ | DRD3 known ✓ | P35462 | 4/20 | 0.97 |
| ▸ | CHRM1 known ✓ | P11229 | 3/20 | 0.97 |
| ▸ | DRD1 known ✓ | P21728 | 3/20 | 0.97 |
| ▸ | SLC6A3 known ✓ | Q01959 | 3/20 | 0.97 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.97 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.97 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.97 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.97 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.97 |
| ▸ | OPRM1 known ✓ | P35372 | 3/20 | 0.85 |
| ▸ | HRH1 known ✓ | P35367 | 3/20 | 0.77 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.77 |
| ▸ | HTR2B known ✓ | P41595 | 2/20 | 0.77 |
| ▸ | CHRM4 known ✓ | P08173 | 1/20 | 0.77 |
| ▸ | CHRM5 known ✓ | P08912 | 1/20 | 0.77 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.77 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlorcyclizine SCHEMBL13724147 | 0.98 | KCNH2 (1.00) | CYP2D6TSHRCYP2C19TDP1KCNH2 | |
| Chlorcyclizine SCHEMBL4383 | 0.98 | KCNH2 (1.00) | CYP2D6TSHRCYP2C19TDP1KCNH2 | |
| Chlorcyclizine SCHEMBL16769331 | 0.98 | KCNH2 (1.00) | CYP2D6TSHRCYP2C19TDP1KCNH2 | |
| Chlorcyclizine SCHEMBL12157065 | 0.98 | KCNH2 (1.00) | CYP2D6TSHRCYP2C19TDP1KCNH2 | |
| Homochlorcyclizine SCHEMBL1977999 | 0.94 | SMN1; SMN2 (1.00) | CYP2D6TSHRCYP2C19TDP1KCNH2 | |
| Homochlorcyclizine SCHEMBL122573 | 0.94 | SMN1; SMN2 (1.00) | CYP2D6TSHRCYP2C19TDP1KCNH2 | |
| Homochlorcyclizine SCHEMBL30402 | 0.92 | DRD3 (1.00) | CYP2D6TSHRCYP2C19TDP1KCNH2 | |
| SCHEMBL2056217 | 0.91 | CHRM2 (0.86) | CYP2D6TSHRCYP2C19TDP1KCNH2 | |
| Cyclizine SCHEMBL97825 | 0.89 | CYP2D6 (0.96) | CYP2D6TSHRCYP2C19TDP1KCNH2 | |
| SCHEMBL7668121 | 0.89 | CHRM2 (0.83) | CYP2D6TSHRCYP2C19TDP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 630 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-222325162-U | Be used for hydrochloric acid chlorocycle Mixer for producing ligustrazine | 焦作福瑞堂制药有限公司 | 2025-01-10 | — | — | CN | claimed |
| US-12036335-B2 | Adhesive containing microparticles | AVERY DENNISON CORPORATION (US) | 2024-07-16 | — | — | US | claimed |
| US-20240189227-A1 | EASY CHEW FORMULATIONS | HALEON US HOLDINGS LLC | 2024-06-13 | — | — | US | claimed |
| EP-4333895-A1 | EASY CHEW FORMULATIONS | Haleon US IP LLC (US) | 2024-03-13 | — | — | EP | claimed |
| EP-4327797-A2 | MULTI PHASE SOFT GEL CAPSULES, APPARATUS AND METHOD THEREOF | Catalent Ontario Limited (CA) | 2024-02-28 | — | — | EP | claimed |
| US-20230310694-A1 | Adhesive Containing Microparticles | AVERY DENNISON CORPORATION | 2023-10-05 | — | — | US | claimed |
| US-20230248734-A1 | ANTIVIRAL COMPOSITION OBTAINED THROUGH DRUG REPOSITIONING | KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2023-08-10 | — | — | US | claimed |
| US-11707549-B2 | Adhesive containing microparticles | AVERY DENNISON CORPORATION (US) | 2023-07-25 | — | — | US | claimed |
| WO-2022235989-A1 | EASY CHEW FORMULATIONS | GLAXOSMITHKLINE CONSUMER HEALTHCARE HOLDINGS (US) LLC (US) | 2022-11-10 | — | — | WO | claimed |
| US-20220142931-A1 | MULTIPHASE SOFT GEL CAPSULES, APPARATUS AND METHOD THEREOF | CATALENT ONTARIO LIMITED (CA) | 2022-05-12 | — | — | US | claimed |
| CN-1030607-C | Tetracyclic compounds having anti-allergic and anti-asthmatic activities, their prepn. and use | SANKYO CO (JP) | 1996-01-03 | — | — | CN | claimed |
| EP-0652774-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER. | PROCTER & GAMBLE (US) | 1995-05-17 | — | — | EP | claimed |
| EP-0608320-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| EP-0608322-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1994-08-03 | — | — | EP | claimed |
| WO-1994002176-A1 | PHARMACEUTICAL COMPOSITION FOR TOPICAL USE CONTAINING A CROSSLINKED CATIONIC POLYMER AND AN ALKOXYLATED ETHER | THE PROCTER & GAMBLE COMPANY (US) | 1994-02-03 | — | — | WO | claimed |
| WO-1993024154-A1 | BIODEGRADABLE CONTROLLED RELEASE MELT-SPUN DELIVERY SYSTEM | FUISZ TECHNOLOGIES, LTD. (US) | 1993-12-09 | — | — | WO | claimed |
| CN-1072863-A | Be used to improve the dermal osmosis system of the reinforcement of medicine localized delivery | RICHARDSON VICKS INC (US) | 1993-06-09 | — | — | CN | claimed |
| WO-1993007902-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| WO-1993007903-A1 | ENHANCED SKIN PENETRATION SYSTEM FOR IMPROVED TOPICAL DELIVERY OF DRUGS | RICHARDSON-VICKS, INC. (US) | 1993-04-29 | — | — | WO | claimed |
| US-4269835-A | Nasal composition for relieving nasal distress | WHITTLE BARRY J | 1981-05-26 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230248734-A1 | ANTIVIRAL COMPOSITION OBTAINED THROUGH DRUG REPOSITIONING | SARS1, EIF2AK2, ACE2 | KCNH2 3255/4885CHRM2 4822/4885ADRA2A 3561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.