Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 7/20 | 0.93 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA7 | P43166 | 2/20 | 0.55 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | CA3 | P07451 | 1/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA6 | P23280 | 1/20 | 0.55 |
| ▸ | CA5A | P35218 | 1/20 | 0.55 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.55 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| (Phenylsulfonyl)Benzene SCHEMBL28119187 | 0.97 | HTR6 (1.00) | HTR6ALDH1A1SMN1; SMN2TSHRCA12 | |
| (Phenylsulfonyl)Benzene SCHEMBL29450723 | 0.97 | HTR6 (1.00) | HTR6ALDH1A1SMN1; SMN2TSHRCA12 | |
| (Phenylsulfonyl)Benzene SCHEMBL29473549 | 0.97 | HTR6 (1.00) | HTR6ALDH1A1SMN1; SMN2TSHRCA12 | |
| (Phenylsulfonyl)Benzene SCHEMBL29775288 | 0.97 | HTR6 (1.00) | HTR6ALDH1A1SMN1; SMN2TSHRCA12 | |
| (Phenylsulfonyl)Benzene SCHEMBL30255 | 0.97 | HTR6 (1.00) | HTR6ALDH1A1SMN1; SMN2TSHRCA12 | |
| (Phenylsulfonyl)Benzene SCHEMBL13735236 | 0.97 | HTR6 (1.00) | HTR6ALDH1A1SMN1; SMN2TSHRCA12 | |
| (Phenylsulfonyl)Benzene SCHEMBL25435825 | 0.93 | HTR6 (0.93) | HTR6ALDH1A1SMN1; SMN2TSHRCA12 | |
| (Phenylsulfonyl)Benzene SCHEMBL9797473 | 0.93 | HTR6 (0.93) | HTR6ALDH1A1SMN1; SMN2TSHRCA12 | |
| (Phenylsulfonyl)Benzene SCHEMBL11362327 | 0.93 | HTR6 (0.93) | HTR6ALDH1A1SMN1; SMN2TSHRCA12 | |
| (Phenylsulfonyl)Benzene SCHEMBL5537560 | 0.93 | HTR6 (0.93) | HTR6ALDH1A1SMN1; SMN2TSHRCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349843-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2013-01-08 | — | — | US | disclosed |
| US-7863445-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-01-04 | — | — | US | disclosed |
| US-20100076188-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-03-25 | — | — | US | disclosed |
| US-6600043-B2 | Pyramidine or triazine derivatives which specifically inhibit the binding of endothelin to the receptor | BASF AKTIENGESELLSCHAFT (DE) | 2003-07-29 | — | — | US | disclosed |
| US-6197958-B1 | CYCLOPENTAPYRIMIDINE DERIVATIVES; ENDOTHELIN RECEPTOR INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2001-03-06 | — | — | US | disclosed |
| US-5969134-A | CARDIOVASCULAR DISORDERS, VASOCONSTRICTION, HYPOTENSIVE AGENTS AND RELEASE OF ENDOTHELINS | BASF AKTIENGESELLSCHAFT (DE) | 1999-10-19 | — | — | US | disclosed |
| EP-0380422-A1 | Process to prepare proteins inhibiting lymphocytotoxicity and the complement, and proteins obtained thereby | FONDATION NATIONALE DE TRANSFUSION SANGUINE (FR) | 1990-08-01 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076188-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | HTR6 1850/4885ALDH1A1 348/4885SMN1; SMN2 2408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.