Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.80 |
| ▸ | MAPT | P10636 | 13/20 | 0.80 |
| ▸ | HPGD | P15428 | 10/20 | 0.72 |
| ▸ | GAA | P10253 | 3/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 12/20 | 0.68 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.68 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.63 |
| ▸ | AIP | O00170 | 1/20 | 0.62 |
| ▸ | SGTA | O43765 | 1/20 | 0.62 |
| ▸ | TOMM70 | O94826 | 1/20 | 0.62 |
| ▸ | STIP1 | P31948 | 1/20 | 0.62 |
| ▸ | PPP5C | P53041 | 1/20 | 0.62 |
| ▸ | DNAJC7 | Q99615 | 1/20 | 0.62 |
| ▸ | STUB1 | Q9UNE7 | 1/20 | 0.62 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 6/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17189283 | 0.89 | ALDH1A1 (0.72) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL14478808 | 0.84 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL1718839 | 0.81 | MAPT (1.00) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL5451299 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL5451294 | 0.78 | ALDH1A1 (0.60) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL18220881 | 0.77 | MAPT (0.68) | ALDH1A1MAPTHPGDGAAKDM4E | |
| SCHEMBL1719520 | 0.77 | ALDH1A1 (1.00) | ALDH1A1MAPTHPGDKDM4EHSD17B10 | |
| SCHEMBL5453282 | 0.76 | AIP (0.71) | ALDH1A1MAPTHPGDKDM4EHSD17B10 | |
| SCHEMBL5451446 | 0.76 | AIP (0.71) | ALDH1A1MAPTHPGDKDM4EHSD17B10 | |
| SCHEMBL5460515 | 0.76 | AIP (0.69) | ALDH1A1MAPTHPGDKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4683912-A1 | SUBSTITUTED THIOPHENE FUSED CYCLOHEXANONE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND THEIR USE AS PHARMACEUTICALS | Neurasic Therapeutics Inc. (CA) | 2026-01-28 | — | — | EP | disclosed |
| WO-2025035205-A1 | PHARMACEUTICAL COMBINATIONS COMPRISING A SUBSTITUTED THIOPHENE FUSED CYCLOHEXANONE DERIVATIVE AND A CYCLOOXYGENASE (COX) INHIBITOR, AND THEIR USE FOR THE TREATMENT OF PAIN | NEURASIC THERAPEUTICS INC. (CA) | 2025-02-20 | — | — | WO | disclosed |
| WO-2024192520-A1 | SUBSTITUTED THIOPHENE FUSED CYCLOHEXANONE DERIVATIVES, COMPOSITIONS COMPRISING THE SAME AND THEIR USE AS PHARMACEUTICALS | NEURASIC THERAPEUTICS INC. (CA) | 2024-09-26 | — | — | WO | disclosed |
| EP-2222326-B2 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | VIB VZW (BE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2222326-B1 | Inhibitors of MALT1-proteolytic activity and uses thereof | VIB VZW (BE) | 2012-04-18 | — | — | EP | disclosed |
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | UNIVERSITEIT GENT (BE) | 2011-01-27 | — | — | US | disclosed |
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | UNIVERSITEIT GENT (BE) | 2011-01-27 | — | — | US | disclosed |
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | UNIVERSITEIT GENT (BE) | 2011-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021548-A1 | INHIBITORS OF MALT1 PROTEOLYTIC ACTIVITY AND USES THEREOF | MMEL1, CTRL, ZFR | ALDH1A1 4353/4885MAPT 4436/4885HPGD 3987/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.