Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Ethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | CA5A | P35218 | 2/20 | 0.50 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | CA1 | P00915 | 4/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | NT5E | P21589 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethane SCHEMBL273722 | 1.00 | — | — | |
| SCHEMBL8596055 | 0.94 | CA2 (0.58) | CA2KDM4ECA5ACA5BCYP3A4 | |
| SCHEMBL246838 | 0.94 | CA2 (0.58) | CA2KDM4ECA5ACA5BCYP3A4 | |
| SCHEMBL105 | 0.94 | — | — | |
| SCHEMBL15109974 | 0.94 | — | — | |
| SCHEMBL128169 | 0.94 | — | — | |
| SCHEMBL25599 | 0.94 | CA2 (0.58) | CA2KDM4ECA5ACA5BCYP3A4 | |
| SCHEMBL579101 | 0.89 | — | — | |
| SCHEMBL20570964 | 0.89 | — | — | |
| SCHEMBL8729088 | 0.89 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117778297-A | Method for establishing nile tilapia testis interstitial cell line | 西部(重庆)科学城种质创制大科学中心 | 2024-03-29 | — | — | CN | disclosed |
| CN-117045678-A | Application of human umbilical cord mesenchymal stem cells and exosomes thereof in preparing medicament for treating physiological testis aging and related diseases | 中山大学附属第一医院 | 2023-11-14 | — | — | CN | disclosed |
| CN-116999537-A | Application of fibroblast growth factor 9 in treating testicular hypofunction | 温州医科大学附属第二医院（温州医科大学附属育英儿童医院） | 2023-11-07 | — | — | CN | disclosed |
| CN-112111548-A | Method for testing that SLC can maintain Leydig and myoid cell homeostasis in adult testis | 温州医科大学附属第二医院、温州医科大学附属育英儿童医院 | 2020-12-22 | — | — | CN | disclosed |
| CN-105255826-B | Method of inducing differentiation and application thereof of the people iPS cell to interstitial glands | 中山大学 | 2019-01-08 | — | — | CN | disclosed |
| US-20180371408-A1 | CELL CULTURES AND METHODS OF USE | UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC. | 2018-12-27 | — | — | US | disclosed |
| US-9937227-B2 | Humanin, analogs and cancer treatment methods and uses thereof | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER (US) | 2018-04-10 | — | — | US | disclosed |
| CN-104212763-B | A kind of separation of interstitial tissue[of testis] stem cell, cultural method and application thereof | 中山大学 | 2017-09-15 | — | — | CN | disclosed |
| CN-104212767-B | A kind of separation for the interstitial tissue[of testis] stem cell for expressing nestin, cultural method and application thereof | 中山大学 | 2017-09-01 | — | — | CN | disclosed |
| US-20160082080-A1 | HUMANIN, ANALOGS AND CANCER TREATMENT METHODS AND USES THEREOF | LOS ANGELES BIOMEDICAL RESEARCH INSTITUTE AT HARBOR-UCLA MEDICAL CENTER | 2016-03-24 | — | — | US | disclosed |
| WO-2003072749-A2 | ENKURIN AND USES THEREOF | UNIVERSITY OF MASSACHUSETS (US) | 2003-09-04 | — | — | WO | disclosed |
| US-6531305-B1 | Isolated nucleic acid encoding a polypeptide; use in diagnosis and therapy of fertility disorders | UNIVERSITY OF MASSACHUSETTS | 2003-03-11 | — | — | US | disclosed |
| US-20020052011-A1 | Method for evaluating and affecting male fertility | UNITED STATES ENVIRONMENTAL PROTECTION AGENCY | 2002-05-02 | — | — | US | disclosed |
| US-6197940-B1 | POLYPEPTIDE FOR THE DETECTION OF DECREASES IN MALE REPRODUCTIVE CAPABILITIES | U.S. ENVIRONMENTAL PROTECTION AGENCY | 2001-03-06 | — | — | US | disclosed |
| EP-1071712-A1 | SP22, A FERTILITY-ASSOCIATED PROTEIN FROM SPERM AND A METHOD FOR EVALUATING AND AFFECTING MALE FERTILITY USING IT | United States Environmental Protection Agency (US) | 2001-01-31 | — | — | EP | disclosed |
| WO-1999054354-A9 | SP22, A FERTILITY-ASSOCIATED PROTEIN FROM SPERM AND A METHOD FOR EVALUATING AND AFFECTING MALE FERTILITY USING IT | US ENVIRONMENT (US) | 1999-12-16 | — | — | WO | disclosed |
| WO-1999054354-A1 | SP22, A FERTILITY-ASSOCIATED PROTEIN FROM SPERM AND A METHOD FOR EVALUATING AND AFFECTING MALE FERTILITY USING IT | U.S. ENVIRONMENTAL PROTECTION AGENCY (US) | 1999-10-28 | — | — | WO | disclosed |
| EP-0877757-A1 | METHOD FOR EVALUATING AND AFFECTING MALE FERTILITY | U.S. Environmental Protection Agency (US) | 1998-11-18 | — | — | EP | disclosed |
| US-5763402-A | Promotion or inhibition of spermatogenesis | THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND (US) | 1998-06-09 | — | — | US | disclosed |
| WO-1997027218-A1 | METHOD FOR EVALUATING AND AFFECTING MALE FERTILITY | U.S. ENVIRONMENTAL PROTECTION AGENCY (US) | 1997-07-31 | — | — | WO | disclosed |