Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.48 |
| ▸ | HRH1 | P35367 | 5/20 | 0.48 |
| ▸ | DRD3 | P35462 | 5/20 | 0.48 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 4/20 | 0.48 |
| ▸ | DRD5 | P21918 | 4/20 | 0.48 |
| ▸ | HRH2 | P25021 | 4/20 | 0.48 |
| ▸ | ADRA1D | P25100 | 4/20 | 0.48 |
| ▸ | HTR7 | P34969 | 4/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.48 |
| ▸ | HTR6 | P50406 | 4/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 4/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 4/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 4/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.48 |
| ▸ | HTR2C | P28335 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10680546 | 0.85 | SLC29A1 (0.54) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL10683077 | 0.85 | HTR2A (0.50) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL5024105 | 0.84 | KCNH2 (0.66) | KCNH2ALDH1A1KDM4EHTT | |
| SCHEMBL10680434 | 0.82 | KMT2A (0.58) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL10676097 | 0.82 | ADRA1A (0.70) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL124103 | 0.81 | L3MBTL1 (0.55) | MEN1KMT2ASMN1; SMN2SIGMAR1ATM | |
| Hydrochloric Acid SCHEMBL2858521 | 0.80 | L3MBTL1 (0.54) | MEN1KMT2ASMN1; SMN2SIGMAR1ATM | |
| SCHEMBL5391121 | 0.79 | L3MBTL1 (0.51) | DRD4DRD2TSHRMAPK1TACR1 | |
| SCHEMBL10681966 | 0.79 | SIGMAR1 (0.53) | HTR2AADRA1AHRH1DRD3OPRK1 | |
| SCHEMBL10680570 | 0.79 | CYP3A4 (0.47) | HTR2AADRA1AHRH1DRD3OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4766125-A | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-08-23 | — | — | US | disclosed |
| EP-0068544-B1 | NOVEL N-ARYL-PIPERAZINEALKANAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-06-03 | — | — | EP | disclosed |
| EP-0068544-A2 | Novel N-aryl-piperazinealkanamides | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-05 | — | — | EP | disclosed |