Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 10/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.52 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10681743 | 0.88 | PDE3B (0.53) | CDC7PDE3BPDE3ACDK5CDK5R1 | |
| SCHEMBL10676837 | 0.85 | CDC7 (0.42) | CDC7UCHL1CHEK2 | |
| SCHEMBL10681929 | 0.85 | CDC7 (0.42) | CDC7PDE3BPDE3AUCHL1KMT2A | |
| SCHEMBL10683120 | 0.85 | PDE3B (0.53) | CDC7PDE3BPDE3ACDK5CDK5R1 | |
| SCHEMBL10681806 | 0.84 | PDE3B (0.55) | CDC7PDE3BPDE3ACDK5CDK5R1 | |
| SCHEMBL10684544 | 0.84 | CDK5 (0.54) | CDC7PDE3BPDE3ACDK5CDK5R1 | |
| SCHEMBL10679788 | 0.82 | MAPT (0.49) | CDC7UCHL1KMT2ANPSR1CHEK2 | |
| SCHEMBL10684242 | 0.80 | GAA (0.49) | CDC7KMT2ANPSR1 | |
| SCHEMBL11078652 | 0.80 | CDC7 (0.61) | CDC7PDE3BPDE3ACDK5CDK5R1 | |
| SCHEMBL10684915 | 0.80 | CDC7 (0.40) | CDC7PDE3BPDE3ACHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |