Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10677653 | 0.89 | UCHL1 (0.53) | MAPTGAAHTTCA1CA2 | |
| SCHEMBL10682462 | 0.86 | MAPT (0.53) | MAPTGAAHTTCA1CA2 | |
| SCHEMBL10676837 | 0.86 | CDC7 (0.42) | MAPTGAAHTTNPC1ALDH1A1 | |
| SCHEMBL10681929 | 0.86 | CDC7 (0.42) | MAPTGAAHTTPARP10NPC1 | |
| SCHEMBL10679716 | 0.85 | ALDH1A1 (0.52) | MAPTGAAHTTCA2NPC1 | |
| SCHEMBL10682046 | 0.85 | MAPT (0.48) | MAPTGAAHTTNPC1ALDH1A1 | |
| SCHEMBL10678289 | 0.82 | CDC7 (0.56) | KMT2AUCHL1NPSR1CHEK2CDC7 | |
| SCHEMBL10999103 | 0.81 | SMN1; SMN2 (0.45) | MAPTGAAPARP10CA1CA2 | |
| SCHEMBL7385630 | 0.81 | MAPT (0.45) | MAPTGAAHTTNPC1ALDH1A1 | |
| SCHEMBL10684242 | 0.81 | GAA (0.49) | MAPTGAAHTTALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |