Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 4/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 4/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CCR9 | P51686 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10677717 | 0.87 | ALDH1A1 (0.44) | PDE3BPDE3AKMT2AALDH1A1HPGD | |
| SCHEMBL10681743 | 0.85 | PDE3B (0.53) | PDE3BPDE3ACDC7CDK5CDK5R1 | |
| SCHEMBL10683120 | 0.85 | PDE3B (0.53) | PDE3BPDE3ACDC7CDK5CDK5R1 | |
| SCHEMBL10678289 | 0.84 | CDC7 (0.56) | PDE3BPDE3ACDC7CDK5CDK5R1 | |
| SCHEMBL10678457 | 0.83 | LMNA (0.40) | PDE3BPDE3ACDC7KMT2AALDH1A1 | |
| SCHEMBL10684544 | 0.83 | CDK5 (0.54) | PDE3BPDE3ACDC7CDK5CDK5R1 | |
| SCHEMBL7384727 | 0.82 | PDE3B (0.62) | PDE3BPDE3ACDC7CDK5CDK5R1 | |
| SCHEMBL10682046 | 0.81 | MAPT (0.48) | KMT2ANPSR1KDM4EALDH1A1HPGD | |
| SCHEMBL10681674 | 0.79 | ALDH1A1 (0.50) | KMT2ANPSR1KDM4EALDH1A1MEN1 | |
| SCHEMBL10680809 | 0.78 | DRD2 (0.36) | PDE3BPDE3ACDC7CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4769380-A | Cardiotonic 5-benzoyl-1,2-dihydro-2-oxo-3-pyridinecarboxylates | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-09-06 | — | — | US | disclosed |