SCHEMBL10679752

SCHEMBL10679752

Cc1cncc(CSC2=C(C(=O)O)N3C(=O)C([C@@H](C)O)C3[C@H]2C)c1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CACNA1C Q13936 1/20 0.42
ESR1 P03372 2/20 0.42
PTGS1 P23219 1/20 0.42
PDE4A P27815 1/20 0.42
ABCC2 Q92887 1/20 0.36
KDM4E B2RXH2 1/20 0.34
LMNA P02545 1/20 0.34
FAP Q12884 1/20 0.33
ELANE P08246 1/20 0.31
HCAR2 Q8TDS4 1/20 0.30
CHRM1 P11229 1/20 0.30
SLC6A4 P31645 1/20 0.30
KCNH2 Q12809 1/20 0.30
SLC29A1 Q99808 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10679749 1.00 CACNA1C (0.42) CACNA1CESR1PTGS1PDE4AABCC2
SCHEMBL10679826 0.89 ESR1 (0.43) CACNA1CESR1PTGS1PDE4AABCC2
SCHEMBL10679836 0.89 ESR1 (0.43) CACNA1CESR1PTGS1PDE4AABCC2
SCHEMBL10682791 0.82 ESR1 (0.44) CACNA1CESR1PTGS1PDE4AABCC2
SCHEMBL10440288 0.82 ESR1 (0.48) CACNA1CESR1PTGS1PDE4AABCC2
SCHEMBL21081301 0.82 ESR1 (0.48) CACNA1CESR1PTGS1PDE4AABCC2
SCHEMBL10683095 0.82 ESR1 (0.43) CACNA1CESR1PTGS1PDE4AABCC2
SCHEMBL10683098 0.82 ESR1 (0.43) CACNA1CESR1PTGS1PDE4AABCC2
SCHEMBL9696757 0.77 ESR1 (0.41) CACNA1CESR1PTGS1PDE4AABCC2
SCHEMBL9741317 0.77 ESR1 (0.41) CACNA1CESR1PTGS1PDE4AABCC2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4732977-A BACTERICIDES BRISTOL MYERS COMPANY (US) 1988-03-22 US disclosed