Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.56 |
| ▸ | SNCA | P37840 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3529585 | 0.85 | POLB (0.56) | GPR35SNCAMAPTHPGDKDM4E | |
| SCHEMBL9198508 | 0.85 | SNCA (0.62) | GPR35SNCAMAPTHPGDKDM4E | |
| SCHEMBL2345266 | 0.83 | GPR35 (0.58) | GPR35SNCAMAPTHPGDKDM4E | |
| SCHEMBL7472630 | 0.82 | TSHR (0.50) | GPR35SNCAMAPTHPGDALDH1A1 | |
| SCHEMBL11328176 | 0.81 | GPR35 (0.56) | GPR35SNCAMAPTHPGDKDM4E | |
| SCHEMBL5175273 | 0.81 | GPR35 (0.56) | GPR35SNCAMAPTHPGDKDM4E | |
| SCHEMBL8063487 | 0.81 | GPR35 (0.56) | GPR35SNCAMAPTHPGDKDM4E | |
| SCHEMBL4962677 | 0.81 | GPR35 (0.56) | GPR35SNCAMAPTHPGDKDM4E | |
| SCHEMBL30279826 | 0.81 | GPR35 (0.56) | GPR35SNCAMAPTHPGDKDM4E | |
| SCHEMBL8603437 | 0.81 | XDH (0.58) | GPR35SNCAMAPTHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4755512-A | Pharmaceutically useful dihydropyridinyldicarboxylate amides and esters incorporating arylpiperazinylalkyl moities | BRISTOL-MYERS COMPANY (US) | 1988-07-05 | — | — | US | disclosed |