Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR5A | P47898 | 7/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HRH2 | P25021 | 1/20 | 0.37 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688814 | 0.89 | SLC6A4 (0.42) | HTR5ASLC6A4HTR2AHTR2CSLC6A2 | |
| SCHEMBL10683964 | 0.86 | HTR5A (0.46) | HTR5ASLC6A4HTR2AHTR2CALOX15 | |
| SCHEMBL10686601 | 0.86 | SLC6A4 (0.47) | HTR5ASLC6A4HTR2AHTR2CHTR6 | |
| SCHEMBL10684924 | 0.84 | HTR5A (0.42) | HTR5ASLC6A4ALOX15KDM4EHSD17B10 | |
| SCHEMBL10689191 | 0.82 | SLC6A4 (0.46) | HTR5ASLC6A4HTR2AHTR2CCHRM2 | |
| SCHEMBL10681792 | 0.80 | SLC6A4 (0.41) | HTR5ASLC6A4HTR2AHTR2CABCB1 | |
| SCHEMBL10681421 | 0.76 | ADRA1D (0.48) | ADRA1AABCB1ABCG2CYP1A2KDM4E | |
| SCHEMBL10688808 | 0.76 | SLC6A4 (0.42) | HTR5ASLC6A4HTR2AHTR2CABCB1 | |
| SCHEMBL10683959 | 0.75 | SLC6A4 (0.41) | HTR5ASLC6A4HTR2AHTR2CABCB1 | |
| SCHEMBL10690031 | 0.74 | ABCB1 (0.52) | HTR5ASLC6A4HTR6ABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4719208-A | 1,2,3,4,5,6-hexahydroazepino(4,5-B)indole derivatives, their preparation, intermediate compounds, and their application in therapeutics | OMNICHEM SOCIETE ANONYME (BE) | 1988-01-12 | — | — | US | disclosed |