SCHEMBL10682013

SCHEMBL10682013

O=c1c(-c2ccccc2)coc2cc(OCC3CCCNC3)ccc12

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP2K1 Q02750 1/20 0.54
ALDH1A1 P00352 6/20 0.54
MAPT P10636 5/20 0.54
NPC1 O15118 5/20 0.54
RAB9A P51151 5/20 0.54
SMN1; SMN2 Q16637 5/20 0.54
MEN1 O00255 3/20 0.54
KMT2A Q03164 3/20 0.54
KDM4E B2RXH2 3/20 0.54
TP53 P04637 2/20 0.54
CYP3A4 P08684 1/20 0.54
HPGD P15428 1/20 0.54
GAA P10253 2/20 0.52
MAPK1 P28482 2/20 0.51
POLB P06746 2/20 0.51
PTGS1 P23219 1/20 0.51
SLC6A2 P23975 1/20 0.51
STAT1 P42224 1/20 0.51
CASP3 P42574 1/20 0.51
HTT P42858 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10685847 0.92 MAP2K1 (0.52) MAP2K1ALDH1A1MAPTNPC1RAB9A
SCHEMBL10682739 0.82 MAOA (0.59) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL10684459 0.80 ABCG2 (0.53) MAP2K1KDM4E
SCHEMBL10681358 0.80 ALDH1A1 (0.55) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL10679105 0.79 IKBKB (0.48) IKBKBCHUKCHRNB2CHRNA4CHRNB4
SCHEMBL10486590 0.79 ALDH1A1 (0.62) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL10682746 0.79 ALDH1A1 (0.66) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL10683624 0.79 NPC1 (0.57) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL10681751 0.78 SLC6A2 (0.59) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2
SCHEMBL10676928 0.77 ALDH1A1 (0.53) ALDH1A1MAPTNPC1RAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4780478-A Aminopropoxy-chromones useful as antidepressants MERCK PATENT GESELLSCHAFT MIT BERSCHRANKTER HAFTUNG (DE) 1988-10-25 US disclosed
US-4508732-A Basic ethers useful as antidepressant agents MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1985-04-02 US disclosed
EP-0031885-B1 BASIC ETHERS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION MERCK PATENT GmbH (DE) 1984-06-27 EP disclosed
US-4376123-A Hexahydroazepinyloxy-chromones useful as antidepressants MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1983-03-08 US disclosed