Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10680577 | 0.89 | LMNA (0.41) | KDM4EALDH1A1KCNH2NFKB1CYP3A4 | |
| SCHEMBL10684949 | 0.87 | ALDH1A1 (0.44) | KDM4EPOLBALDH1A1KCNH2NFKB1 | |
| SCHEMBL11161398 | 0.84 | ALDH1A1 (0.42) | KDM4EALDH1A1KCNH2NFKB1CYP3A4 | |
| SCHEMBL10680876 | 0.80 | ALDH1A1 (0.43) | KDM4EPOLBALDH1A1KCNH2NFKB1 | |
| SCHEMBL10682507 | 0.79 | ALDH1A1 (0.44) | KDM4EALDH1A1KCNH2CYP3A4CYP2D6 | |
| SCHEMBL10679600 | 0.79 | ALDH1A1 (0.43) | KDM4EALDH1A1KCNH2NFKB1CYP3A4 | |
| SCHEMBL30564541 | 0.78 | CYP3A4 (0.62) | KDM4EKCNH2NFKB1CYP3A4CYP2D6 | |
| SCHEMBL10682231 | 0.78 | ALDH1A1 (0.42) | KDM4EALDH1A1KCNH2NFKB1CYP3A4 | |
| SCHEMBL1777934 | 0.74 | ALDH1A1 (0.57) | POLBALDH1A1KCNH2NFKB1CYP3A4 | |
| SCHEMBL19448262 | 0.72 | MAPT (0.34) | KDM4EPOLBALDH1A1CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4766125-A | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-08-23 | — | — | US | disclosed |
| EP-0068544-B1 | NOVEL N-ARYL-PIPERAZINEALKANAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-06-03 | — | — | EP | disclosed |
| EP-0068544-A2 | Novel N-aryl-piperazinealkanamides | JANSSEN PHARMACEUTICA N.V. (BE) | 1983-01-05 | — | — | EP | disclosed |