Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.53 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.53 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | HTR2B | P41595 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | MLNR | O43193 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8554173 | 0.97 | ALDH1A1 (0.55) | ALDH1A1DRD4MEN1KMT2APOLB | |
| SCHEMBL1778375 | 0.91 | ALDH1A1 (0.49) | ALDH1A1DRD4MEN1KMT2APOLB | |
| SCHEMBL9031046 | 0.91 | DRD4 (0.60) | ALDH1A1DRD4MEN1KMT2APOLB | |
| SCHEMBL2327539 | 0.89 | ALDH1A1 (0.64) | ALDH1A1DRD4MEN1KMT2APOLB | |
| Pyrrocaine SCHEMBL25718 | 0.86 | MEN1 (0.70) | ALDH1A1DRD4MEN1KMT2APOLB | |
| SCHEMBL4034304 | 0.86 | TP53 (0.56) | ALDH1A1MEN1KMT2AKCNH2CYP1A2 | |
| SCHEMBL7288776 | 0.85 | POLB (0.74) | ALDH1A1MEN1KMT2APOLBCHRM3 | |
| SCHEMBL2096761 | 0.85 | MEN1 (0.73) | ALDH1A1DRD4MEN1KMT2APOLB | |
| SCHEMBL22407740 | 0.85 | MEN1 (0.73) | ALDH1A1DRD4MEN1KMT2APOLB | |
| Pincainide SCHEMBL2110148 | 0.85 | MEN1 (0.73) | ALDH1A1DRD4MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 153 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103664829-A | Ranolazine synthesis technology | CHENGDU YILUKANG MEDICAL TECHNOLOGY & SERVICE CO LTD | 2014-03-26 | — | — | CN | claimed |
| CN-103570645-A | Method for preparing N-(2,6-dimethyl phenyl)-2-(1-piperazine)acetamide | SHANGHAI DESANO CHEMICAL PHARM | 2014-02-12 | — | — | CN | claimed |
| US-8541578-B2 | Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide | JANSSEN PHARMACEUTICA, N.V. (BE) | 2013-09-24 | — | — | US | claimed |
| EP-2586774-A1 | METHOD FOR PREPARATION OF RANOLAZINE | Shanghai Kuoikee Laboratories Co., Ltd (CN) | 2013-05-01 | — | — | EP | claimed |
| CN-102367241-B | Preparation method of ranolazine | QILU TIANHE PHARMACEUTICAL CO LTD | 2013-04-17 | — | — | CN | claimed |
| US-20130090475-A1 | Process for the Preparation of Ranolazine | ZHEJIANG JIANFENG HAIZHOU PHARMACEUTICAL CO., LTD. (CN) | 2013-04-11 | — | — | US | claimed |
| US-20110223213-A1 | HIGHLY PURE RANOLAZINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ACTAVIS GROUP PTC EHF (IS) | 2011-09-15 | — | — | US | claimed |
| EP-2356097-A2 | HIGHLY PURE RANOLAZINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | Actavis Group PTC ehf. (IS) | 2011-08-17 | — | — | EP | claimed |
| US-20110151258-A1 | PREPARATION OF RANOLAZINE | DR. REDDY'S LABORATORIES LTD. (IN) | 2011-06-23 | — | — | US | claimed |
| EP-2328873-A2 | PREPARATION OF RANOLAZINE | Dr. Reddy's Laboratories Ltd. (IN) | 2011-06-08 | — | — | EP | claimed |
| WO-2010043976-A2 | HIGHLY PURE RANOLAZINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ACTAVIS GROUP PTC EHF (IS) | 2010-04-22 | — | — | WO | claimed |
| WO-2010023687-A2 | PREPARATION OF RANOLAZINE, ITS SALTS AND INTERMEDIATES THEREOF | SHODHANA LABORATORIES LIMITED (IN) | 2010-03-04 | — | — | WO | claimed |
| WO-2010025370-A2 | PREPARATION OF RANOLAZINE | DR. REDDY'S LABORATORIES LTD. (IN) | 2010-03-04 | — | — | WO | claimed |
| CN-100494187-C | Method for synthesizing Ranolazine | JIE YAN (CN) | 2009-06-03 | — | — | CN | claimed |
| EP-1517900-B1 | PROCESS FOR THE PRODUCTION OF N-(2,6-DIMETHYL-PHENYL)-2-PIPERAZIN-1-YL-ACETAMIDE | JANSSEN PHARMACEUTICA NV (BE) | 2009-05-27 | — | — | EP | claimed |
| WO-2008047388-A2 | IMPROVED PROCESS FOR THE PREPARATION OF RANOLAZINE | IND-SWIFT LABORATORIES LIMITED (IN) | 2008-04-24 | — | — | WO | claimed |
| CN-1915982-A | Method for synthesizing Ranolazine | YAN JIE (CN) | 2007-02-21 | — | — | CN | claimed |
| US-20050240018-A1 | Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-10-27 | — | — | US | claimed |
| EP-1517900-A1 | PROCESS FOR THE PRODUCTION OF N-(2,6-DIMETHYL-PHENYL)-2-PIPERAZIN-1-YL-ACETAMIDE | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-03-30 | — | — | EP | claimed |
| WO-2004000824-A1 | PROCESS FOR THE PRODUCTION OF N-(2,6-DIMETHYL-PHENYL)-2-PIPERAZIN-1-YL-ACETAMIDE | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-12-31 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110223213-A1 | HIGHLY PURE RANOLAZINE OR A PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | REN, ADRB3, RAN | ALDH1A1 2045/4885DRD4 1176/4885MEN1 4060/4885 |
| US-20130090475-A1 | Process for the Preparation of Ranolazine | RANBP1, RANBP2, RAN | ALDH1A1 279/4885DRD4 2063/4885MEN1 3207/4885 |
| US-20050240018-A1 | Process for the production of n-(2,6-dimethyl-phenyl)-2-piperazin-1-yl-acetamide | SCN5A, SCN2A, NAA15 | ALDH1A1 1020/4885DRD4 1230/4885MEN1 4527/4885 |
| US-20110151258-A1 | PREPARATION OF RANOLAZINE | RANBP1, RAN, ACHE | ALDH1A1 949/4885DRD4 602/4885MEN1 4039/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.