Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8210078 | 0.85 | EDNRB (0.55) | EDNRBEDNRA | |
| SCHEMBL9369015 | 0.74 | EDNRB (0.76) | EDNRBEDNRA | |
| SCHEMBL6776490 | 0.74 | EDNRB (0.76) | EDNRBEDNRA | |
| Darusentan SCHEMBL1068546 | 0.71 | EDNRB (1.00) | EDNRBEDNRA | |
| Darusentan SCHEMBL795084 | 0.71 | EDNRB (1.00) | EDNRBEDNRA | |
| SCHEMBL1067548 | 0.71 | EDNRB (0.70) | EDNRBEDNRA | |
| SCHEMBL8113638 | 0.70 | EDNRB (0.77) | EDNRBEDNRA | |
| SCHEMBL8115354 | 0.69 | EDNRB (0.71) | EDNRBEDNRA | |
| SCHEMBL6776058 | 0.69 | EDNRB (0.71) | EDNRBEDNRA | |
| SCHEMBL12228356 | 0.69 | EDNRB (0.71) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349843-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2013-01-08 | — | — | US | disclosed |
| US-7863445-B2 | Carboxylic acid derivatives, their preparation and use | ABBOTT GMBH & CO. KG (DE) | 2011-01-04 | — | — | US | disclosed |
| US-20100076188-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100076188-A1 | NOVEL CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND USE | HCAR1, HCAR2, HCAR3 | EDNRB 359/4885EDNRA 313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.