SCHEMBL10684286

SCHEMBL10684286

CCCc1cc(OC)ccc1OCCCNc1cnn(C(C)C)c(=O)c1Cl

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 4/20 0.44
MTNR1B P49286 4/20 0.44
KDM4E B2RXH2 1/20 0.41
RAB9A P51151 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
BPTF Q12830 1/20 0.40
CNR2 P34972 2/20 0.39
PDE9A O76083 2/20 0.38
MAPT P10636 1/20 0.38
NR1H2 P55055 1/20 0.36
NR1H3 Q13133 1/20 0.36
PPARG P37231 2/20 0.36
PDE1A P54750 1/20 0.36
PDE1B Q01064 1/20 0.36
PDE1C Q14123 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10681057 0.93 BPTF (0.42) MTNR1AMTNR1BKDM4ERAB9ASMN1; SMN2
SCHEMBL10685216 0.89 SMN1; SMN2 (0.41) MTNR1AMTNR1BKDM4ERAB9ASMN1; SMN2
SCHEMBL10367314 0.88 MTNR1A (0.45) MTNR1AMTNR1BKDM4ERAB9ASMN1; SMN2
SCHEMBL10366527 0.88 KDM4E (0.39) MTNR1AMTNR1BKDM4ERAB9ASMN1; SMN2
SCHEMBL10366274 0.86 KDM4E (0.41) KDM4ERAB9ASMN1; SMN2BPTFCNR2
SCHEMBL10366159 0.86 BPTF (0.40) MTNR1AMTNR1BKDM4ERAB9ASMN1; SMN2
SCHEMBL10368185 0.84 PTGER4 (0.41) KDM4ERAB9ASMN1; SMN2BPTFCNR2
SCHEMBL10368098 0.82 KDM4E (0.43) MTNR1AMTNR1BKDM4ERAB9ASMN1; SMN2
SCHEMBL10366155 0.81 KDM4E (0.40) MTNR1AMTNR1BKDM4ERAB9ASMN1; SMN2
SCHEMBL10677550 0.81 KDM4E (0.41) MTNR1AMTNR1BKDM4ERAB9ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4783462-A 3(2H)pyridazinone, and anti-allergic agent containing it NISSAN CHEMICAL INDUSTRIES LTD. (JP) 1988-11-08 US claimed