SCHEMBL1068828

SCHEMBL1068828

CCCCCC(CC)Oc1ccc(-c2nc(-c3ccc(C)cc3C)nc(-c3ccc(C)cc3C)n2)c(O)c1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TLR8 Q9NR97 2/20 0.35
NPC1 O15118 3/20 0.34
CNR1 P21554 3/20 0.34
CNR2 P34972 3/20 0.34
LIMK1 P53667 1/20 0.34
LIMK2 P53671 1/20 0.34
TP53 P04637 1/20 0.33
POLB P06746 1/20 0.33
NFKB1 P19838 1/20 0.33
MAPK1 P28482 1/20 0.33
RAB9A P51151 1/20 0.33
NFKB2 Q00653 1/20 0.33
RELA Q04206 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
ALDH2 P05091 2/20 0.33
PLK1 P53350 2/20 0.33
LMNA P02545 2/20 0.33
NPSR1 Q6W5P4 2/20 0.33
MAPT P10636 1/20 0.33
TSHR P16473 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7709567 0.88 TLR8 (0.36) TLR8NPC1CNR1CNR2TP53
SCHEMBL10253638 0.87 CNR1 (0.36) TLR8NPC1CNR1CNR2TP53
SCHEMBL26629793 0.86 ALDH2 (0.47) SMN1; SMN2ALDH2PLK1
SCHEMBL8822539 0.84 PLA2G4B (0.35) TLR8NPC1CNR2TP53POLB
SCHEMBL30575191 0.84 CNR1 (0.34) TLR8NPC1CNR1CNR2TP53
SCHEMBL26629797 0.83 ALDH2 (0.46) SMN1; SMN2ALDH2EGLN1
SCHEMBL3801058 0.83 CNR2 (0.33) TLR8NPC1CNR1CNR2TP53
SCHEMBL5720595 0.82 NPC1 (0.42) NPC1CNR1CNR2TP53MAPK1
SCHEMBL7592006 0.82 NPC1 (0.42) NPC1CNR1CNR2TP53MAPK1
SCHEMBL25373352 0.82 ALDH2 (0.42) TLR8NPC1CNR1CNR2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2545896-B1 Sunscreen compositions HENKEL AG & CO KGAA (DE) 2019-10-16 EP disclosed
EP-2545900-B1 Sun screen compounds with high sun block factor and pleasant feel HENKEL AG & CO KGAA (DE) 2018-08-08 EP disclosed
EP-2545901-B1 Emulsion base for sun screen compounds HENKEL AG & CO KGAA (DE) 2017-11-22 EP disclosed
EP-2451533-B1 METHOD FOR PRODUCING STABLE EMULSIONS, IN PARTICULAR SUNSCREEN FORMULATIONS HENKEL AG & CO KGAA (DE) 2015-09-30 EP disclosed
EP-2313076-B1 RINSE-OFF PRODUCTS HAVING A BENEFICIAL EFFECT ON THE SKIN HENKEL AG & CO KGAA (DE) 2014-07-09 EP disclosed
EP-2654667-A1 FOAMABLE COSMETIC COMPOSITION CONTAINING FOAMING AGENTS FOR SKIN AND BODY CARE Henkel AG & Co. KGaA (DE) 2013-10-30 EP disclosed
EP-2617408-A2 Two phase face cleaner with high ocular and mucous membrane compatibility Henkel AG&Co. KGAA (DE) 2013-07-24 EP disclosed
EP-2545896-A2 Sunscreen compositions Henkel AG & Co. KGaA (DE) 2013-01-16 EP disclosed
EP-2545900-A2 Sun screen compounds with high sun block factor and pleasant feel Henkel AG & Co. KGaA (DE) 2013-01-16 EP disclosed
EP-2545902-A2 Sunscreen compositions with improved antioxidative potential for protecting the skin from IR radiation Henkel AG & Co. KGaA (DE) 2013-01-16 EP disclosed
WO-2012084970-A1 FOAMABLE COSMETIC COMPOSITION CONTAINING FOAMING AGENTS FOR SKIN AND BODY CARE HENKEL AG & CO. KGAA (DE) 2012-06-28 WO disclosed
EP-2451533-A2 METHOD FOR PRODUCING STABLE EMULSIONS, IN PARTICULAR SUNSCREEN FORMULATIONS Henkel AG & Co. KGaA (DE) 2012-05-16 EP disclosed
EP-2332513-A2 Sunscreen compositions with improved sun protection factor Henkel AG & Co. KGaA (DE) 2011-06-15 EP disclosed
US-20110097288-A1 Sun Protection Composition HENKEL AG & CO. KGAA (DE) 2011-04-28 US disclosed
WO-2011003655-A2 METHOD FOR PRODUCING STABLE EMULSIONS, IN PARTICULAR SUNSCREEN FORMULATIONS HENKEL AG & CO. KGAA (DE) 2011-01-13 WO disclosed
EP-2266527-A2 Sun screen compositions with improved antioxidant potential Henkel AG & Co. KGaA (DE) 2010-12-29 EP disclosed
EP-2201927-A2 Sun screen compounds Henkel AG & Co. KGaA (DE) 2010-06-30 EP disclosed
EP-2201928-A2 Sun screen compounds Henkel AG & Co. KGaA (DE) 2010-06-30 EP disclosed
EP-2201929-A2 Sun screen compounds Henkel AG & Co. KGaA (DE) 2010-06-30 EP disclosed
EP-2127633-A1 Sun screen compounds Henkel AG & Co. KGaA (DE) 2009-12-02 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110097288-A1 Sun Protection Composition MGLL, DAGLA, ERCC4 TLR8 1740/4885NPC1 1036/4885CNR1 4325/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.