Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11317303 | 0.84 | ALDH1A1 (0.47) | SIRT2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL9438991 | 0.82 | ALDH1A1 (0.66) | SIRT2ALDH1A1CYP19A1MAPTMEN1 | |
| SCHEMBL5857849 | 0.81 | HTR2C (0.54) | SIRT2ALDH1A1DDB1CRBNCYP19A1 | |
| SCHEMBL11263779 | 0.81 | ALDH1A1 (0.64) | SIRT2ALDH1A1DDB1CRBNCYP19A1 | |
| SCHEMBL1664746 | 0.78 | ALDH1A1 (0.40) | SIRT2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL13659875 | 0.78 | ALDH1A1 (0.50) | ALDH1A1MAPTMEN1KMT2ATDP1 | |
| SCHEMBL28860894 | 0.76 | ALDH1A1 (0.54) | SIRT2ALDH1A1CYP19A1MEN1KMT2A | |
| SCHEMBL31121835 | 0.76 | CTRC (0.47) | SIRT2ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL28722327 | 0.76 | DDB1 (0.55) | SIRT2ALDH1A1DDB1CRBNCYP19A1 | |
| SCHEMBL28571847 | 0.75 | RECQL (0.47) | SIRT2ALDH1A1DDB1CRBNCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4731457-A | 1-substituted, 2,3-diphenyl-3-hydroxymethyl pyrrolidines, where the 2- and/or 3-phenyl can be substituted | THE PURDUE FREDERICK COMPANY (US) | 1988-03-15 | — | — | US | disclosed |
| US-4639529-A | Analgesic and anti-inflammatory compounds | THE PURDUE FREDERICK COMPANY (US) | 1987-01-27 | — | — | US | disclosed |
| US-4476311-A | Analgesic 4-carboxy-pyrrolidin-2-one compound | THE PURDUE FREDERICK COMPANY (US) | 1984-10-09 | — | — | US | disclosed |