Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | SLC10A2 | Q12908 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10688710 | 0.74 | ADORA1 (0.52) | L3MBTL1MEN1KMT2ADHFRALDH1A1 | |
| SCHEMBL10686590 | 0.73 | MEN1 (0.57) | L3MBTL1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL10686218 | 0.73 | DHFR (0.43) | L3MBTL1MEN1KMT2ADHFRSLC10A2 | |
| SCHEMBL10682446 | 0.73 | DHFR (0.43) | L3MBTL1DHFRSLC10A2ALDH1A1NPC1 | |
| SCHEMBL3931265 | 0.73 | KDM4E (0.55) | L3MBTL1MEN1KMT2AALDH1A1NPC1 | |
| SCHEMBL603548 | 0.72 | KDM4E (0.48) | L3MBTL1MEN1KMT2AALDH1A1RAB9A | |
| SCHEMBL6592858 | 0.71 | EGLN1 (0.43) | L3MBTL1MEN1KMT2AALDH1A1KDM4E | |
| Dimethylamine SCHEMBL7490478 | 0.71 | POLB (0.44) | L3MBTL1MEN1KMT2ADHFRSLC10A2 | |
| SCHEMBL16266535 | 0.70 | L3MBTL1 (0.53) | L3MBTL1MEN1KMT2AALDH1A1PDE4A | |
| SCHEMBL10689891 | 0.70 | PDE4B (0.51) | L3MBTL1ALDH1A1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725600-A | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1988-02-16 | — | — | US | disclosed |
| EP-0168262-A2 | Pyrimidine derivatives, processes for preparation thereof and use thereof | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1986-01-15 | — | — | EP | disclosed |