Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 4/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | GRM6 | O15303 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865549 | 0.87 | ALDH1A1 (0.41) | KDM4EALDH1A1CSNK1A1CLK4ABL1 | |
| SCHEMBL15894822 | 0.86 | KDM4E (0.46) | KDM4EALDH1A1ABL1NOS3NOS1 | |
| SCHEMBL3190550 | 0.83 | CSNK1A1 (0.47) | KDM4EALDH1A1CSNK1A1CLK4ABL1 | |
| SCHEMBL8650942 | 0.83 | ALDH1A1 (0.38) | KDM4EALDH1A1CSNK1A1CLK4ABL1 | |
| SCHEMBL2339904 | 0.82 | CSNK1A1 (0.46) | KDM4EALDH1A1CSNK1A1CLK4ABL1 | |
| SCHEMBL20489454 | 0.80 | HTT (0.44) | KDM4EALDH1A1CSNK1A1CLK4ABL1 | |
| SCHEMBL26194109 | 0.79 | TSHR (0.37) | KDM4EALDH1A1CSNK1A1CLK4HTT | |
| SCHEMBL27883134 | 0.79 | CSNK1A1 (0.47) | KDM4ECSNK1A1CLK4ABL1HTT | |
| SCHEMBL30937680 | 0.78 | ALDH1A1 (0.43) | KDM4EALDH1A1ABL1HTTHSD17B10 | |
| SCHEMBL8655458 | 0.78 | ALDH1A1 (0.43) | KDM4EALDH1A1ABL1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4725687-A | ANTITUMOR AGENTS; SIDE EFFECT REDUCTION; POTENCY | SOUTHERN RESEARCH INSTITUTE (US) | 1988-02-16 | — | — | US | disclosed |