SCHEMBL10690851

SCHEMBL10690851

COc1cc(OC)nc(NC(=O)NS(=O)(=O)NS(=O)(=O)c2ccccc2CCOS(=O)(=O)c2ccc(C)cc2)n1

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.46
TP53 P04637 1/20 0.41
GLA P06280 1/20 0.41
MAPT P10636 1/20 0.41
MEN1 O00255 1/20 0.38
USP2 O75604 1/20 0.38
KMT2A Q03164 1/20 0.38
CDK1 P06493 1/20 0.37
TSHR P16473 2/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
LMNA P02545 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10690199 0.96 TSHR (0.43) GAATP53GLAMAPTMEN1
SCHEMBL10691846 0.89 KDM4E (0.35) GAAMAPTMEN1USP2KMT2A
SCHEMBL10690785 0.83 SMN1; SMN2 (0.46) GAATP53GLAMAPTCDK1
SCHEMBL10692932 0.83 GAA (0.48) GAATP53GLAMAPTKMT2A
SCHEMBL10693829 0.80 TSHR (0.46) GAATP53GLAMAPTCDK1
SCHEMBL10755508 0.79 GAA (0.55) GAATP53GLAMAPTKMT2A
SCHEMBL10691806 0.77 GAA (0.53) GAATP53GLAMAPTKMT2A
SCHEMBL10687755 0.76 ALDH1A1 (0.41) GAATP53MAPTSMN1; SMN2
SCHEMBL11114757 0.76 GAA (0.44) GAAMEN1USP2KMT2ACDK1
SCHEMBL10692577 0.75 GAA (0.55) GAATP53GLAMAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0106512-B1 HERBICIDAL ORTHO-ALKYL- AND ORTHO-ALKENYL-SUBSTITUTED BENZENESULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-18 EP claimed
US-4699650-A Herbicidal ortho-alkyl-and ortho-alkenyl substituted benzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-10-13 US claimed
EP-0106512-A2 Herbicidal ortho-alkyl- and ortho-alkenyl-substituted benzenesulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-25 EP claimed
US-4770690-A Herbicidal ortho-alkyl- and ortho-alkenyl-substituted benzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-09-13 US disclosed
EP-0106512-B1 HERBICIDAL ORTHO-ALKYL- AND ORTHO-ALKENYL-SUBSTITUTED BENZENESULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-18 EP disclosed
US-4699650-A Herbicidal ortho-alkyl-and ortho-alkenyl substituted benzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-10-13 US disclosed
US-4678502-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-07-07 US disclosed
EP-0106512-A2 Herbicidal ortho-alkyl- and ortho-alkenyl-substituted benzenesulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-25 EP disclosed