SCHEMBL10691846

SCHEMBL10691846

COc1nc(C)nc(NC(=O)NS(=O)(=O)NS(=O)(=O)c2ccccc2CCOS(=O)(=O)c2ccc(C)cc2)n1

nearest known ligand 0.59

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.35
NPC1 O15118 1/20 0.35
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.34
LMNA P02545 1/20 0.34
GAA P10253 1/20 0.34
MEN1 O00255 1/20 0.33
USP2 O75604 1/20 0.33
KMT2A Q03164 1/20 0.33
PSMD10 O75832 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10690851 0.89 GAA (0.46) MAPTLMNAGAAMEN1USP2
SCHEMBL10690199 0.87 TSHR (0.43) MAPTLMNAGAAMEN1USP2
SCHEMBL10687755 0.83 ALDH1A1 (0.41) KDM4ENPC1ALDH1A1MAPTGAA
SCHEMBL10680118 0.81 ALDH1A1 (0.45) KDM4ENPC1ALDH1A1MAPTGAA
SCHEMBL10707044 0.81 MAPT (0.37) KDM4ENPC1ALDH1A1MAPTGAA
SCHEMBL10692420 0.79 ALDH1A1 (0.43) KDM4ENPC1ALDH1A1MAPTGAA
SCHEMBL6459389 0.78 ALDH1A1 (0.47) KDM4ENPC1ALDH1A1MAPTGAA
SCHEMBL11122289 0.76 ALDH1A1 (0.47) KDM4ENPC1ALDH1A1MAPTGAA
SCHEMBL10415106 0.76 GAA (0.55) KDM4EALDH1A1MAPTLMNAGAA
SCHEMBL11047586 0.75 ALDH1A1 (0.46) KDM4ENPC1ALDH1A1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0106512-B1 HERBICIDAL ORTHO-ALKYL- AND ORTHO-ALKENYL-SUBSTITUTED BENZENESULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-18 EP claimed
US-4678502-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-07-07 US claimed
EP-0106512-A2 Herbicidal ortho-alkyl- and ortho-alkenyl-substituted benzenesulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-25 EP claimed
US-4770690-A Herbicidal ortho-alkyl- and ortho-alkenyl-substituted benzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-09-13 US disclosed
EP-0106512-B1 HERBICIDAL ORTHO-ALKYL- AND ORTHO-ALKENYL-SUBSTITUTED BENZENESULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-18 EP disclosed
US-4699650-A Herbicidal ortho-alkyl-and ortho-alkenyl substituted benzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-10-13 US disclosed
US-4678502-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-07-07 US disclosed
EP-0106512-A2 Herbicidal ortho-alkyl- and ortho-alkenyl-substituted benzenesulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-25 EP disclosed