SCHEMBL10692932

SCHEMBL10692932

COc1cc(OC)nc(NC(=O)NS(=O)(=O)NS(=O)(=O)c2ccccc2CCCl)n1

nearest known ligand 0.54

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.48
MAPT P10636 2/20 0.44
TP53 P04637 1/20 0.44
GLA P06280 1/20 0.44
CDK1 P06493 1/20 0.42
CYP1A2 P05177 1/20 0.39
KMT2A Q03164 1/20 0.38
KDM4E B2RXH2 1/20 0.38
NPC1 O15118 1/20 0.38
ALDH1A1 P00352 1/20 0.38
TSHR P16473 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10693829 0.94 TSHR (0.46) GAAMAPTTP53GLACDK1
SCHEMBL10691180 0.92 GAA (0.55) GAAMAPTTP53GLACDK1
SCHEMBL10692420 0.89 ALDH1A1 (0.43) GAAMAPTTP53KDM4ENPC1
SCHEMBL10690785 0.85 SMN1; SMN2 (0.46) GAAMAPTTP53GLACDK1
SCHEMBL10646472 0.83 GAA (0.57) GAAMAPTTP53GLACDK1
SCHEMBL10690851 0.83 GAA (0.46) GAAMAPTTP53GLACDK1
SCHEMBL10755508 0.81 GAA (0.55) GAAMAPTTP53GLACDK1
SCHEMBL10692577 0.81 GAA (0.55) GAAMAPTTP53GLACDK1
SCHEMBL11124125 0.80 GAA (0.58) GAAMAPTTP53GLACDK1
SCHEMBL10691806 0.80 GAA (0.53) GAAMAPTTP53GLACDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0106512-B1 HERBICIDAL ORTHO-ALKYL- AND ORTHO-ALKENYL-SUBSTITUTED BENZENESULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-18 EP claimed
US-4699650-A Herbicidal ortho-alkyl-and ortho-alkenyl substituted benzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-10-13 US claimed
EP-0106512-A2 Herbicidal ortho-alkyl- and ortho-alkenyl-substituted benzenesulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-25 EP claimed
US-4770690-A Herbicidal ortho-alkyl- and ortho-alkenyl-substituted benzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-09-13 US disclosed
EP-0106512-B1 HERBICIDAL ORTHO-ALKYL- AND ORTHO-ALKENYL-SUBSTITUTED BENZENESULFONAMIDES E.I. DU PONT DE NEMOURS AND COMPANY (US) 1988-05-18 EP disclosed
US-4699650-A Herbicidal ortho-alkyl-and ortho-alkenyl substituted benzenesulfonamides E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-10-13 US disclosed
US-4678502-A PLANT GROWTH REGULATORS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1987-07-07 US disclosed
EP-0106512-A2 Herbicidal ortho-alkyl- and ortho-alkenyl-substituted benzenesulfonamides E.I. DU PONT DE NEMOURS AND COMPANY (US) 1984-04-25 EP disclosed