Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 9/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10377619 | 0.82 | NOTUM (0.43) | CRBNNOTUMSIGMAR1 | |
| SCHEMBL10671026 | 0.82 | NOTUM (0.40) | CRBNPARP1NOTUM | |
| SCHEMBL10688845 | 0.81 | CRBN (0.36) | CRBN | |
| SCHEMBL10688848 | 0.81 | CRBN (0.36) | CRBN | |
| SCHEMBL10692994 | 0.76 | SRD5A1 (0.41) | CRBNAKR1C3AKR1C2 | |
| SCHEMBL10674343 | 0.76 | SRD5A1 (0.40) | CRBNAKR1C3AKR1C2ALDH1A1SIGMAR1 | |
| SCHEMBL10687019 | 0.76 | CRBN (0.40) | CRBNAKR1C3AKR1C2PARP1HDAC6 | |
| SCHEMBL7621632 | 0.74 | CRBN (0.51) | CRBNKDM4EALDH1A1MAPTHDAC6 | |
| SCHEMBL10377620 | 0.73 | CRBN (0.40) | CRBNPARP1KDM4EALDH1A1MAPT | |
| SCHEMBL10669896 | 0.73 | ACHE (0.50) | CRBNPARP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4742061-A | Benzoc[c]-1,5-naphthyridines and related compounds as memory enhancing agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-05-03 | — | — | US | disclosed |