Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 9/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10686493 | 0.89 | MCL1 (0.40) | KDM4EHPGDALDH1A1GAAHSD17B10 | |
| SCHEMBL19751545 | 0.81 | DAO (0.58) | KDM4EHPGDALDH1A1GAAHSD17B10 | |
| SCHEMBL29891877 | 0.79 | IMPDH2 (0.51) | KDM4EHPGDALDH1A1GAAGALR3 | |
| SCHEMBL8139952 | 0.78 | FLT3 (0.49) | GAAIDH1DAO | |
| SCHEMBL7264461 | 0.78 | IDH1 (0.51) | KDM4EHPGDALDH1A1GAAMCL1 | |
| SCHEMBL10691248 | 0.78 | DAO (0.58) | IDH1DAO | |
| SCHEMBL7501391 | 0.77 | IDH1 (0.55) | KDM4EHPGDALDH1A1GAATSHR | |
| SCHEMBL7499153 | 0.77 | IDH1 (0.58) | KDM4EALDH1A1GAAHSD17B10MAPT | |
| SCHEMBL10692726 | 0.76 | KDM4E (0.45) | KDM4EHPGDALDH1A1GAATSHR | |
| SCHEMBL1903750 | 0.75 | BRD4 (0.55) | KDM4EHPGDALDH1A1GAAMCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4735948-A | (1H-tetrazol-5-yl)-2(1H)-quinolinones and-naphthyridones and antiallergic use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0120484-B1 | (1H-TETRAZOL-5-YL)TETRAZOLO (1,5-A)-QUINOLINES AND RELATED COMPOUNDS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-22 | — | — | EP | disclosed |
| EP-0120483-B1 | (1H-TETRAZOL-5-YL)-2(1H)-QUINOLINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| US-4496569-A | Antiallergic (1H-tetrazol-5-yl)tetrazolo[1,5-a]quinolines and derivatives thereof | THE DOW CHEMICAL COMPANY (US) | 1985-01-29 | — | — | US | disclosed |
| EP-0120483-A1 | (1H-tetrazol-5-yl)-2(1H)-quinolinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | disclosed |
| EP-0120484-A1 | (1H-tetrazol-5-yl)tetrazolo (1,5-a)-quinolines and related compounds | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | disclosed |