Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 11/20 | 0.54 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 4/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10687997 | 0.81 | PPARG (0.48) | MTNR1AMTNR1BPPARG | |
| SCHEMBL10688284 | 0.74 | MTNR1A (0.62) | MTNR1AMTNR1BPOLBHDAC1HDAC2 | |
| SCHEMBL430674 | 0.73 | MTNR1A (0.61) | MTNR1AMTNR1BPOLBHDAC1HDAC2 | |
| SCHEMBL10683484 | 0.71 | PPARG (0.49) | MTNR1APPARG | |
| SCHEMBL4553401 | 0.71 | MTNR1A (0.58) | MTNR1AMTNR1BPOLBHDAC1HDAC2 | |
| SCHEMBL10688765 | 0.70 | MTNR1A (0.41) | MTNR1AMTNR1BPPARG | |
| SCHEMBL28422916 | 0.70 | MTNR1A (0.58) | MTNR1AMTNR1BPOLBHDAC1HDAC2 | |
| Lithium Ion SCHEMBL4553399 | 0.70 | MTNR1A (0.57) | MTNR1AMTNR1BPOLBHDAC1HDAC2 | |
| SCHEMBL6694328 | 0.69 | MTNR1A (0.60) | MTNR1AMTNR1BPOLBHDAC1HDAC2 | |
| SCHEMBL10685775 | 0.69 | PPARG (0.49) | PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4738972-A | Hypoglycemic thiazolidinediones | PFIZER INC. (US) | 1988-04-19 | — | — | US | disclosed |