Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | LTK | P29376 | 1/20 | 0.46 |
| ▸ | GRK5 | P34947 | 1/20 | 0.46 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.46 |
| ▸ | CDK8 | P49336 | 1/20 | 0.46 |
| ▸ | PRKX | P51817 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.46 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.46 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.46 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10908011 | 0.84 | ALDH1A1 (0.49) | CHEK1DAPK3MAP4K4RETPIM1 | |
| SCHEMBL8285712 | 0.81 | LMNA (0.50) | CHEK1DAPK3MAP4K4RETPIM1 | |
| SCHEMBL10810832 | 0.81 | ALDH1A1 (0.36) | ALDH1A1CYP1A2CYP3A4LMNACYP2D6 | |
| SCHEMBL30808271 | 0.81 | EPAS1 (0.41) | ALDH1A1CYP1A2CYP3A4LMNACYP2D6 | |
| SCHEMBL21821393 | 0.81 | EPAS1 (0.41) | ALDH1A1CYP1A2CYP3A4LMNACYP2D6 | |
| Water SCHEMBL20531414 | 0.79 | ALDH1A1 (0.35) | ALDH1A1CYP1A2CYP3A4LMNACYP2D6 | |
| SCHEMBL10692092 | 0.77 | NPC1 (0.43) | ALDH1A1CYP1A2SLC40A1NPC1MEN1 | |
| SCHEMBL31602107 | 0.72 | CHEK1 (0.53) | CHEK1DAPK3MAP4K4RETPIM1 | |
| SCHEMBL3160581 | 0.72 | CHEK1 (0.53) | CHEK1DAPK3MAP4K4RETPIM1 | |
| SCHEMBL7950905 | 0.71 | ABCC8 (0.56) | CHEK1DAPK3MAP4K4RETPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4743692-A | N-(pyridinylalkyl)-thieno-or benzo-isothiazol-3-amine derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1988-05-10 | — | — | US | disclosed |
| EP-0081955-B1 | BENZO-FUSED HETEROCYCLIC COMPOUNDS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1987-01-21 | — | — | EP | disclosed |
| US-4490527-A | Benzo-fused heterocyclic anti-ulcer agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1984-12-25 | — | — | US | disclosed |
| EP-0081955-A2 | Benzo-fused heterocyclic compounds | AMERICAN HOME PRODUCTS CORPORATION (US) | 1983-06-22 | — | — | EP | disclosed |