Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SCD | O00767 | 4/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PARG | Q86W56 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | CBFB | Q13951 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.34 |
| ▸ | FADS1 | O60427 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690924 | 0.90 | NPBWR1 (0.40) | KDRNPBWR1PDGFRBFGFR1SCD | |
| SCHEMBL7506795 | 0.80 | ALDH1A1 (0.51) | KDRPDGFRBKDM4EALDH1A1MAPT | |
| SCHEMBL10691644 | 0.79 | DAO (0.50) | KDRPDGFRBFGFR1CDK5CDK5R1 | |
| SCHEMBL7503986 | 0.79 | IDH1 (0.43) | KDRPDGFRBFGFR1KDM4EALDH1A1 | |
| SCHEMBL7499608 | 0.77 | KDR (0.60) | KDRPDGFRBFGFR1KDM4EALDH1A1 | |
| Water SCHEMBL10691885 | 0.76 | KDM4E (0.42) | KDRPDGFRBFGFR1KDM4EALDH1A1 | |
| SCHEMBL7507967 | 0.75 | KDR (0.43) | KDRKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL7507959 | 0.73 | KDR (0.43) | KDRKDM4EALDH1A1MAPTHPGD | |
| SCHEMBL10691865 | 0.73 | GRIN2D (0.46) | KDM4EALDH1A1MAPTHPGDHSD17B10 | |
| SCHEMBL10804501 | 0.71 | ALDH1A1 (0.35) | NPBWR1KDM4EALDH1A1MAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4735948-A | (1H-tetrazol-5-yl)-2(1H)-quinolinones and-naphthyridones and antiallergic use thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-04-05 | — | — | US | disclosed |
| EP-0120483-B1 | (1H-TETRAZOL-5-YL)-2(1H)-QUINOLINONES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1987-04-01 | — | — | EP | disclosed |
| EP-0120483-A1 | (1H-tetrazol-5-yl)-2(1H)-quinolinones | MERRELL DOW PHARMACEUTICALS INC. (US) | 1984-10-03 | — | — | EP | disclosed |