Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.60 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7351360 | 0.93 | HTR2C (0.56) | HTR2CROCK2ALDH1A1MEN1KMT2A | |
| SCHEMBL2800406 | 0.84 | POLB (0.50) | HTR2CALDH1A1DDB1CRBNMEN1 | |
| SCHEMBL8494181 | 0.84 | POLB (0.50) | HTR2CALDH1A1DDB1CRBNMEN1 | |
| SCHEMBL13410161 | 0.82 | ROCK2 (0.49) | HTR2CROCK2ALDH1A1MEN1KMT2A | |
| SCHEMBL19327276 | 0.81 | ROCK2 (0.48) | HTR2CROCK2ALDH1A1MEN1KMT2A | |
| SCHEMBL22365570 | 0.81 | ROCK2 (0.48) | HTR2CROCK2ALDH1A1MEN1KMT2A | |
| SCHEMBL17079983 | 0.80 | ROCK2 (0.61) | HTR2CROCK2ALDH1A1HSD11B1MAPT | |
| SCHEMBL19858927 | 0.79 | DDB1 (0.48) | HTR2CALDH1A1DDB1CRBNMEN1 | |
| SCHEMBL14301511 | 0.79 | ROCK2 (0.47) | HTR2CROCK2ALDH1A1MEN1KMT2A | |
| SCHEMBL22365585 | 0.77 | ROCK2 (0.47) | HTR2CROCK2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270093-A2 | Lactam derivatives, processes for the preparation thereof, pharmaceutical compositions comprising the same, and the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties | TANABE SEIYAKU CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |