Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.61 |
| ▸ | HTR2C | P28335 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17080069 | 0.82 | ROCK2 (0.46) | ROCK2HTR2CLMNAHTR2B | |
| SCHEMBL10691676 | 0.80 | HTR2C (0.60) | ROCK2HTR2CALDH1A1MAPTHTR2B | |
| SCHEMBL17080007 | 0.80 | ROCK2 (0.49) | ROCK2HTR2CMAPT | |
| SCHEMBL17079989 | 0.77 | ROCK2 (0.59) | ROCK2 | |
| SCHEMBL18048773 | 0.76 | ROCK2 (1.00) | ROCK2POLB | |
| SCHEMBL17079976 | 0.75 | ROCK2 (0.45) | ROCK2HTR2C | |
| SCHEMBL7351360 | 0.75 | HTR2C (0.56) | ROCK2HTR2CALDH1A1MAPTHSD11B1 | |
| SCHEMBL17079996 | 0.74 | ROCK2 (0.45) | ROCK2ALDH1A1RECQLMAPTHSD11B1 | |
| SCHEMBL18083927 | 0.74 | ROCK2 (0.64) | ROCK2HTR2CMAPT | |
| SCHEMBL20924955 | 0.73 | ROCK2 (0.64) | ROCK2ALDH1A1RECQLLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3116877-A1 | CHEMICAL COMPOUNDS ACTING AS PERK INHIBITORS | Glaxosmithkline Intellectual Property (No. 2) Limited (GB) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015136463-A1 | CHEMICAL COMPOUNDS ACTING AS PERK INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-09-17 | — | — | WO | disclosed |
| WO-2015136463-A1 | CHEMICAL COMPOUNDS ACTING AS PERK INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED (GB) | 2015-09-17 | — | — | WO | disclosed |