Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CREBBP | Q92793 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | PDE4A | P27815 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10700217 | 0.86 | KDM4E (0.41) | KDM4EMEN1KMT2ARAB9AMAPT | |
| SCHEMBL10696318 | 0.85 | KDM4E (0.41) | KDM4EMEN1KMT2ARAB9AMAPT | |
| SCHEMBL10695498 | 0.85 | ALDH1A1 (0.43) | KDM4EMEN1KMT2AMAPTCREBBP | |
| SCHEMBL10697577 | 0.84 | KDM4E (0.40) | KDM4EMEN1KMT2ARAB9AMAPT | |
| SCHEMBL10698820 | 0.84 | KDM4E (0.42) | KDM4EMEN1KMT2ARAB9AMAPK1 | |
| SCHEMBL10696477 | 0.83 | KDM4E (0.42) | KDM4EMEN1KMT2ARAB9AMAPT | |
| SCHEMBL10695491 | 0.82 | MAPT (0.42) | KDM4EMEN1KMT2ARAB9AMAPT | |
| SCHEMBL10696420 | 0.82 | ELANE (0.43) | KDM4EMEN1KMT2ARAB9AMAPT | |
| SCHEMBL10698284 | 0.82 | MEN1 (0.39) | KDM4EMEN1KMT2ARAB9AMAPT | |
| SCHEMBL10695292 | 0.81 | PDE4A (0.38) | MEN1KMT2ACREBBPBRD4PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |