Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.37 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.37 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696477 | 0.94 | KDM4E (0.42) | KDM4EMAPTRAB9AMEN1MAPK1 | |
| SCHEMBL10695491 | 0.93 | MAPT (0.42) | KDM4EMAPTRAB9AMEN1MAPK1 | |
| SCHEMBL10700217 | 0.92 | KDM4E (0.41) | KDM4EMAPTRAB9AMEN1MAPK1 | |
| SCHEMBL10697577 | 0.90 | KDM4E (0.40) | KDM4EMAPTRAB9AMEN1MAPK1 | |
| SCHEMBL10698284 | 0.89 | MEN1 (0.39) | KDM4EMAPTRAB9AMEN1MAPK1 | |
| SCHEMBL10696042 | 0.86 | ALDH1A1 (0.39) | KDM4EALDH1A1KCNA5KCNJ5KCNJ3 | |
| SCHEMBL10696420 | 0.86 | ELANE (0.43) | KDM4EMAPTRAB9AMEN1MAPK1 | |
| SCHEMBL10691679 | 0.85 | KDM4E (0.45) | KDM4EMAPTRAB9AMEN1MAPK1 | |
| SCHEMBL10699508 | 0.80 | AURKA (0.39) | — | |
| SCHEMBL10696397 | 0.80 | ALDH1A1 (0.40) | KDM4EMAPTMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268178-A1 | Pyrrolo-benzimidazoles, medicaments containing these compounds and process for their preparation | Dr. Karl Thomae GmbH (DE) | 1988-05-25 | — | — | EP | disclosed |