Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 2/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | BCL9 | O00512 | 1/20 | 0.40 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 2/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.39 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6997448 | 0.84 | GLA (0.52) | KMT2ATNKSCCNA2CDK2CCNA1 | |
| SCHEMBL10572047 | 0.77 | TNKS (0.43) | KMT2ASMN1; SMN2HPGDTNKSCCNA2 | |
| SCHEMBL3739324 | 0.75 | HDAC6 (0.54) | TNKSCCNA2CDK2CCNA1HDAC1 | |
| SCHEMBL6789099 | 0.74 | TNKS (0.48) | TNKSCCNA2CDK2CCNA1HDAC1 | |
| SCHEMBL3584808 | 0.73 | ALDH1A1 (0.49) | TNKSCCNA2CDK2CCNA1HDAC1 | |
| SCHEMBL14155611 | 0.73 | HDAC1 (0.55) | KMT2ATNKSCCNA2CDK2CCNA1 | |
| SCHEMBL3586685 | 0.73 | ALDH1A1 (0.49) | TNKSCCNA2CDK2CCNA1HDAC1 | |
| SCHEMBL6783997 | 0.72 | CCNA2 (0.60) | KMT2ASMN1; SMN2TNKSCCNA2CDK2 | |
| SCHEMBL5591295 | 0.72 | LMNA (0.53) | TNKSCCNA2CDK2CCNA1HDAC1 | |
| SCHEMBL10574183 | 0.72 | TDP1 (0.55) | KMT2AL3MBTL1TDP1MEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0270093-A2 | Lactam derivatives, processes for the preparation thereof, pharmaceutical compositions comprising the same, and the use of such derivatives for the manufacture of a medicament having valuable therapeutic properties | TANABE SEIYAKU CO., LTD. (JP) | 1988-06-08 | — | — | EP | disclosed |