Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.47 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27574758 | 0.85 | MAPT (0.50) | MAPTPOLBNPC1ADORA2ACASP1 | |
| SCHEMBL14916404 | 0.83 | MAPT (0.61) | MAPTPOLBGAANPC1ADORA2A | |
| SCHEMBL21044774 | 0.83 | MAPT (0.53) | MAPTPOLBGAAALDH1A1MEN1 | |
| SCHEMBL29612169 | 0.83 | MAPT (0.53) | MAPTPOLBGAAALDH1A1MEN1 | |
| SCHEMBL10701348 | 0.81 | AKR1C3 (0.61) | MAPTPOLBGAAPTGDR2AKR1C3 | |
| SCHEMBL25197720 | 0.80 | MAPT (0.49) | MAPTPOLBGAANPC1ALDH1A1 | |
| SCHEMBL15792959 | 0.79 | MAPT (0.56) | MAPTPOLBGAANPC1ADORA2A | |
| SCHEMBL15626666 | 0.79 | MAPT (0.58) | MAPTPOLBGAAAKR1C3ALDH1A1 | |
| SCHEMBL26738 | 0.79 | MAPT (1.00) | MAPTPOLBGAANPC1ADORA2A | |
| SCHEMBL30453594 | 0.79 | MAPT (0.58) | MAPTPOLBGAAAKR1C3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11136299-B2 | Benzodiazepine derivatives for use in the treatment of Chlamydiales infections | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2021-10-05 | — | — | US | disclosed |
| EP-3085375-B1 | BENZODIAZEPINE DERIVATIVES FOR USE IN THE TREATMENT OF CHLAMYDIALES INFECTIONS | COMMISSARIAT ENERGIE ATOMIQUE (FR) | 2018-06-27 | — | — | EP | disclosed |
| US-20160311783-A1 | Benzodiazepine Derivatives for Use in the Treatment of Chlamydiales Infections | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2016-10-27 | — | — | US | disclosed |
| EP-3085375-A1 | BENZODIAZEPINE DERIVATIVES FOR USE IN THE TREATMENT OF CHLAMYDIALES INFECTIONS | COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES (FR) | 2016-10-26 | — | — | EP | disclosed |
| US-4754024-A | Fibre-reactive azo dyes containing vinylsulfonyl or analogous groups | CIBA-GEIGY CORPORATION | 1988-06-28 | — | — | US | disclosed |
| EP-0112285-B1 | REACTIVE DYES, THEIR PREPARATION AND THEIR USE | CIBA-GEIGY AG (CH) | 1987-03-18 | — | — | EP | disclosed |
| EP-0112285-A2 | Reactive dyes, their preparation and their use | CIBA-GEIGY AG (CH) | 1984-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11136299-B2 | Benzodiazepine derivatives for use in the treatment of Chlamydiales infections | CNR1, GABBR1, GABRA1 | MAPT 3212/4885POLB 4094/4885GAA 1830/4885 |
| US-20160311783-A1 | Benzodiazepine Derivatives for Use in the Treatment of Chlamydiales Infections | CNR1, GABBR1, GABRA1 | MAPT 3212/4885POLB 4094/4885GAA 1830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.