Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.33 |
| ▸ | ATR | Q13535 | 2/20 | 0.33 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10691113 | 0.82 | CYP11B2 (0.32) | — | |
| SCHEMBL10554712 | 0.74 | MAPT (0.42) | MKNK1PIK3CBMKNK2CCNE1CDK2 | |
| SCHEMBL10550033 | 0.69 | ALDH1A1 (0.46) | MKNK1PIK3CBMKNK2CCNE1CDK2 | |
| SCHEMBL11622951 | 0.69 | ALDH1A1 (0.41) | MAPTRAB9AALDH1A1HTT | |
| SCHEMBL10737848 | 0.63 | MAPT (0.45) | MAPTALDH1A1HTT | |
| SCHEMBL10552778 | 0.63 | POLB (0.55) | MKNK1MKNK2CCNE1CDK2HSF1 | |
| SCHEMBL17265639 | 0.60 | POLB (0.58) | MAPTRAB9ALCKPOLBALDH1A1 | |
| SCHEMBL6625200 | 0.60 | PIK3CB (0.74) | MKNK1PIK3CBMKNK2LCKHRH4 | |
| SCHEMBL6626031 | 0.60 | PIK3CB (0.74) | MKNK1PIK3CBMKNK2LCKHRH4 | |
| SCHEMBL6629587 | 0.60 | PIK3CB (0.65) | MKNK1PIK3CBMKNK2LCKHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0255704-A2 | Pyridazinone derivatives, process for their preparation and their use as medicines | Roche Diagnostics GmbH (DE) | 1988-02-10 | — | — | EP | disclosed |