Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.39 |
| ▸ | ERN1 | O75460 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.37 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 2/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1068372 | 0.72 | PI4KA (0.50) | ALDH1A1KMT2AEGFRL3MBTL1NPC1 | |
| SCHEMBL1716704 | 0.72 | CCR1 (0.55) | ALDH1A1KMT2AKDM4EL3MBTL1NPC1 | |
| SCHEMBL31132323 | 0.71 | KDM4E (0.52) | KMT2AKDM4EL3MBTL1NPC1HSP90AA1 | |
| SCHEMBL2008893 | 0.71 | KDM4E (0.52) | KMT2AKDM4EL3MBTL1NPC1HSP90AA1 | |
| SCHEMBL6371727 | 0.71 | EGFR (0.40) | ALDH1A1KMT2AEGFRKDM4EL3MBTL1 | |
| SCHEMBL2013872 | 0.69 | CCR1 (0.33) | CCR1CCR8 | |
| SCHEMBL6837820 | 0.69 | EGFR (0.41) | ALDH1A1KMT2AEGFRKDM4EL3MBTL1 | |
| SCHEMBL2210491 | 0.69 | EGFR (0.41) | ALDH1A1KMT2AEGFRKDM4EL3MBTL1 | |
| SCHEMBL12559949 | 0.69 | EGFR (0.41) | ALDH1A1KMT2AEGFRKDM4EL3MBTL1 | |
| SCHEMBL2041433 | 0.69 | PI4KA (0.52) | ALDH1A1KMT2AEGFRKDM4EHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014145512-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2014-09-18 | — | — | WO | disclosed |
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY (CN) | 2012-10-11 | — | — | US | disclosed |
| WO-2012079079-A1 | PRODUCTION OF INDUCED PLURIPOTENT STEM CELLS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-06-14 | — | — | WO | disclosed |
| EP-2456761-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY AND METHODS OF USE THEREOF | President and Fellows of Harvard College (US) | 2012-05-30 | — | — | EP | disclosed |
| WO-2011011522-A2 | POTENT SMALL MOLECULE INHIBITORS OF AUTOPHAGY, AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-01-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120258975-A1 | Potent Small Molecule Inhibitors of Autophagy, and Methods of Use Thereof | ATG7, BECN1, SQSTM1 | ALDH1A1 4492/4885KMT2A 4516/4885EGFR 2099/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.