Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.50 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.50 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.50 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.47 |
| ▸ | ERN1 | O75460 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.43 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | LTK | P29376 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10703592 | 0.79 | SMN1; SMN2 (0.50) | PI4KAPI4K2BPI4K2API4KBPDE4A | |
| SCHEMBL160404 | 0.79 | PI4KA (0.50) | PI4KAPI4K2BPI4K2API4KBPDE4A | |
| SCHEMBL2008893 | 0.73 | KDM4E (0.52) | ERN1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL31132323 | 0.73 | KDM4E (0.52) | ERN1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL28587968 | 0.73 | PARP1 (0.49) | MAP4K4SMN1; SMN2PARP1MAPTLMNA | |
| SCHEMBL29985318 | 0.73 | PARP1 (0.49) | MAP4K4SMN1; SMN2PARP1MAPTLMNA | |
| SCHEMBL28358026 | 0.73 | CSF1R (0.39) | EGFRMAP4K4PARP1MEN1KMT2A | |
| SCHEMBL1069237 | 0.72 | ALDH1A1 (0.42) | ERN1EGFRSMN1; SMN2PARP1RAB9A | |
| SCHEMBL276986 | 0.71 | PI4KA (0.56) | PI4KAPI4K2BPI4K2API4KBPDE4A | |
| 4-Aminoquinazoline SCHEMBL30455007 | 0.71 | PI4KA (0.78) | PI4KAPI4K2BPI4K2API4KBPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 103 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164458-B | Monoacylglycerol lipase modulators | 詹森药业有限公司 | 2024-09-13 | — | — | CN | claimed |
| CN-113164459-B | Monoacylglycerol lipase modulators | 詹森药业有限公司 | 2024-09-03 | — | — | CN | claimed |
| CN-117946083-A | Quinazoline derivative containing piperonal as well as synthesis method and application thereof | 贵州大学 | 2024-04-30 | — | — | CN | claimed |
| CN-117466942-A | Chiral secondary phosphine oxide compound, chiral quinazolinone/pyrimidinone ring derivative based on chiral secondary phosphine oxide compound and application of chiral quinazolinone/pyrimidinone ring derivative | 中山大学 | 2024-01-30 | — | — | CN | claimed |
| CN-116693554-A | Quinazoline-4-ketone compound containing 1,2, 4-triazole [3,4-b ] [1,3,4] thiadiazole, preparation and application | 贵州大学 | 2023-09-05 | — | — | CN | claimed |
| CN-113200927-B | Synthesis method of N- (3-ethynylphenyl) -quinazoline-4-amine | 上海橡实化学有限公司 | 2022-08-26 | — | — | CN | claimed |
| CN-113200927-A | Synthesis method of N- (3-ethynylphenyl) -quinazoline-4-amine | 上海橡实化学有限公司 | 2021-08-03 | — | — | CN | claimed |
| CN-113164458-A | Monoacylglycerol lipase modulators | 詹森药业有限公司 | 2021-07-23 | — | — | CN | claimed |
| CN-108358896-B | Compound for preparing medicine for preventing and treating crop pathogenic bacteria and preparation method | 贵州大学 | 2021-01-08 | — | — | CN | claimed |
| CN-106995438-B | A kind of substituted quinazoline -4- ketone compounds and preparation method thereof and medical usage | 中国科学院上海药物研究所 | 2019-09-20 | — | — | CN | claimed |
| CN-106995438-A | One class substituted quinazoline -4- ketone compounds and preparation method thereof and medical usage | 中国科学院上海药物研究所 | 2017-08-01 | — | — | CN | claimed |
| CN-104610169-A | Quinazoline-containing thioether substituted pentadiene ketone derivatives, and preparation method and application thereof | UNIV GUIZHOU | 2015-05-13 | — | — | CN | claimed |
| US-7459415-B1 | Lubricant for thin film storage media | SEAGATE TECHNOLOGY LLC (US) | 2008-12-02 | — | — | US | claimed |
| CN-1597671-A | Quinazoline deriative and preparation method and bioactivity | UNIV GUIZHOU (CN) | 2005-03-23 | — | — | CN | claimed |
| US-20030138670-A1 | Lubricant for thin film storage media | SEAGATE TECHNOLOGY LLC | 2003-07-24 | — | — | US | claimed |
| US-12577243-B2 | Monoacylglycerol lipase modulators | JANSSEN PHARMACEUTICA NV (BE) | 2026-03-17 | — | — | US | disclosed |
| US-20240327410-A1 | Monoacylglycerol Lipase Modulators | JANSSEN PHARMACEUTICA NV (BE) | 2024-10-03 | — | — | US | disclosed |
| US-20030138670-A1 | Lubricant for thin film storage media | SEAGATE TECHNOLOGY LLC | 2003-07-24 | — | — | US | disclosed |
| CN-1090621-C | Process for preparing quinazolin-4-one derivatives | OTSUKA PHARMA CO LTD (JP) | 2002-09-11 | — | — | CN | disclosed |
| CN-1193967-A | Process for producing quinazoline-4-one derivatives | OTSUKA PHARMA CO LTD (US) | 1998-09-23 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12577243-B2 | Monoacylglycerol lipase modulators | MGLL, LPL, FAAH | PI4KA 1537/4885PI4K2B 1874/4885PI4K2A 1993/4885 |
| US-20240327410-A1 | Monoacylglycerol Lipase Modulators | MGLL, LPL, PNLIP | PI4KA 1736/4885PI4K2B 1856/4885PI4K2A 1876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.