Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | PAM | P19021 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8460589 | 0.86 | ALDH1A1 (0.50) | L3MBTL1MAPK1ALDH1A1PAMTSHR | |
| SCHEMBL10693506 | 0.79 | MAPT (0.52) | ALDH1A1CES1HTTMAPTKMT2A | |
| SCHEMBL10692273 | 0.77 | TSHR (0.43) | L3MBTL1MAPK1ALDH1A1PAMTSHR | |
| SCHEMBL8463651 | 0.77 | TSHR (0.49) | L3MBTL1MAPK1ALDH1A1PAMTSHR | |
| SCHEMBL10694773 | 0.76 | MAPT (0.46) | ALDH1A1SMN1; SMN2MAPTPOLB | |
| SCHEMBL8717382 | 0.76 | KMT2A (0.44) | L3MBTL1MAPK1ALDH1A1TDP1HTT | |
| SCHEMBL13387222 | 0.73 | TSHR (0.49) | L3MBTL1MAPK1ALDH1A1PAMTSHR | |
| SCHEMBL28954433 | 0.73 | TSHR (0.49) | L3MBTL1MAPK1ALDH1A1PAMTSHR | |
| SCHEMBL1279129 | 0.73 | CES1 (0.57) | L3MBTL1MAPK1ALDH1A1PAMTSHR | |
| SCHEMBL1346095 | 0.73 | TSHR (0.56) | L3MBTL1MAPK1ALDH1A1PAMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0098743-B1 | PHENYL ALPHA-ACYLOXYACETAMIDE DERIVATES AND THEIR THERAPEUTIC USE | Yu, Ruey J., Dr. (US) | 1988-09-28 | — | — | EP | claimed |
| EP-0098743-A1 | Phenyl alpha-acyloxyacetamide derivates and their therapeutic use | Yu, Ruey J., Dr. (US) | 1984-01-18 | — | — | EP | claimed |
| US-4518789-A | Phenyl alpha-acyloxyacetamide derivatives and their therapeutic use | YU RUEY J | 1985-05-21 | — | — | US | disclosed |
| EP-0098743-A1 | Phenyl alpha-acyloxyacetamide derivates and their therapeutic use | Yu, Ruey J., Dr. (US) | 1984-01-18 | — | — | EP | disclosed |