Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TK1 | P04183 | 2/20 | 0.64 |
| ▸ | BCHE | P06276 | 3/20 | 0.59 |
| ▸ | TYMP | P19971 | 1/20 | 0.58 |
| ▸ | TYMS | P04818 | 4/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10692639 | 1.00 | TK1 (0.64) | TK1BCHETYMPTYMSCYP1A2 | |
| SCHEMBL5702260 | 1.00 | TK1 (0.64) | TK1BCHETYMPTYMSCYP1A2 | |
| SCHEMBL6294757 | 0.93 | TYMS (0.56) | TK1BCHETYMPTYMS | |
| SCHEMBL6294759 | 0.93 | TYMS (0.56) | TK1BCHETYMPTYMS | |
| SCHEMBL15235291 | 0.93 | TYMS (0.56) | TK1BCHETYMPTYMS | |
| SCHEMBL17123679 | 0.93 | TYMS (0.56) | TK1BCHETYMPTYMS | |
| SCHEMBL7541144 | 0.93 | TYMS (0.56) | TK1BCHETYMPTYMS | |
| SCHEMBL13255800 | 0.93 | TYMS (0.56) | TK1BCHETYMPTYMS | |
| SCHEMBL21133906 | 0.93 | TYMS (0.56) | TK1BCHETYMPTYMS | |
| SCHEMBL3599668 | 0.93 | TYMS (0.56) | TK1BCHETYMPTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10874752-B2 | MIBG analogs and uses thereof | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2020-12-29 | — | — | US | disclosed |
| US-20180256761-A1 | MIBG ANALOGS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2018-09-13 | — | — | US | disclosed |
| EP-3352746-A1 | MIBG ANALOGS AND USES THEREOF | Board of Regents of the University of Nebraska (US) | 2018-08-01 | — | — | EP | disclosed |
| WO-2017053834-A1 | MIBG ANALOGS AND USES THEREOF | BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA (US) | 2017-03-30 | — | — | WO | disclosed |
| EP-0252989-A1 | 2'-DEOXY-5-TRIFLUOROMETHYLURIDINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) | 1988-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874752-B2 | MIBG analogs and uses thereof | SLC6A2, SLC18A2, SLC18A3 | TK1 212/4885BCHE 1060/4885TYMP 325/4885 |
| US-20180256761-A1 | MIBG ANALOGS AND USES THEREOF | SLC6A2, SLC18A2, SLC18A3 | TK1 212/4885BCHE 1060/4885TYMP 325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.