Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL841729 | 0.71 | MAPT (0.44) | ALDH1A1TSHRHSD11B1HTTKMT2A | |
| SCHEMBL10370674 | 0.68 | RAD52 (0.48) | ALDH1A1TSHRSCN9AHTTKMT2A | |
| SCHEMBL31389171 | 0.67 | TSHR (0.58) | ALDH1A1TSHRHTTKMT2AMAPT | |
| SCHEMBL10368739 | 0.66 | HSD11B1 (0.45) | ALDH1A1HSD11B1KMT2AMAPTKDM4E | |
| SCHEMBL27524948 | 0.66 | SCN9A (0.62) | ALDH1A1SCN9AKMT2ATP53 | |
| SCHEMBL10689170 | 0.66 | ADRA1A (0.40) | ALDH1A1TSHRSCN9AHSD11B1HTT | |
| SCHEMBL29475767 | 0.65 | PDK2 (0.42) | ALDH1A1HSD11B1KMT2AMAPTKDM4E | |
| SCHEMBL10370026 | 0.65 | SCN9A (0.43) | ALDH1A1TSHRSCN9AHSD11B1HTT | |
| SCHEMBL10691597 | 0.63 | ADRA1A (0.39) | ALDH1A1TSHRSCN9AMAPTRAD52 | |
| SCHEMBL10690604 | 0.63 | TDP1 (0.42) | ALDH1A1TSHRSCN9AMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |