Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 4/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.39 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694665 | 0.83 | RAD52 (0.36) | ADRA1AADRA1DADRA1BRAD52ALDH1A1 | |
| SCHEMBL10693548 | 0.82 | RAD52 (0.35) | ADRA1AADRA1DADRA1BRAD52ALDH1A1 | |
| SCHEMBL10695401 | 0.82 | RAD52 (0.42) | RAD52ALDH1A1MAPTTSHRADAMTS5 | |
| SCHEMBL10691306 | 0.81 | ALDH1A1 (0.41) | RAD52ALDH1A1MAPTTSHRTDP1 | |
| SCHEMBL10696619 | 0.81 | RAD52 (0.34) | ADRA1AADRA1DADRA1BRAD52ALDH1A1 | |
| SCHEMBL10689170 | 0.81 | ADRA1A (0.40) | ADRA1AADRA1DADRA1BALDH1A1MAPT | |
| SCHEMBL10691593 | 0.80 | L3MBTL1 (0.42) | ALDH1A1MAPTSCN9ATSHRL3MBTL1 | |
| SCHEMBL10690604 | 0.78 | TDP1 (0.42) | ADRA1AADRA1DADRA1BALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL10758557 | 0.77 | DRD2 (0.41) | ADRA1AADRA1DADRA1BALDH1A1DRD2 | |
| Hydrochloric Acid SCHEMBL10695756 | 0.75 | MEN1 (0.47) | ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4778793-A | CONTROLLING CALCIUM CONCENTRATION-CARDIOVASCULAR DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-10-18 | — | — | US | disclosed |
| EP-0212216-A1 | Dihydroquinolinone derivatives, processes for their preparation, medicaments containing them, the use of these medicaments, and intermediates for their preparation | HOECHST AKTIENGESELLSCHAFT (DE) | 1987-03-04 | — | — | EP | disclosed |