Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.73 |
| ▸ | HTR1D | P28221 | 8/20 | 0.66 |
| ▸ | HTR1B | P28222 | 7/20 | 0.64 |
| ▸ | HTR1A | P08908 | 6/20 | 0.64 |
| ▸ | HTR2A | P28223 | 2/20 | 0.61 |
| ▸ | HTR2C | P28335 | 2/20 | 0.61 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.61 |
| ▸ | HTR3B | O95264 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | HTR1E | P28566 | 1/20 | 0.61 |
| ▸ | HTR1F | P30939 | 1/20 | 0.61 |
| ▸ | HTR7 | P34969 | 1/20 | 0.61 |
| ▸ | HTR2B | P41595 | 1/20 | 0.61 |
| ▸ | HTR3A | P46098 | 1/20 | 0.61 |
| ▸ | HTR5A | P47898 | 1/20 | 0.61 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8869175 | 0.93 | HTR1D (0.70) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| Oxalic Acid SCHEMBL8869617 | 0.90 | KMT2A (0.87) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| Oxalic Acid SCHEMBL8870335 | 0.90 | KMT2A (0.75) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| Oxalic Acid SCHEMBL10693370 | 0.87 | SLC6A4 (0.71) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| Mebufotenin SCHEMBL7205139 | 0.85 | KMT2A (1.00) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8869909 | 0.85 | HTR1D (0.72) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| Oxalic Acid SCHEMBL8868845 | 0.83 | KMT2A (0.68) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| Oxalic Acid SCHEMBL8870216 | 0.83 | KMT2A (0.74) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8869593 | 0.82 | HTR1D (0.71) | KMT2AHTR1DHTR1BHTR1AHTR2A | |
| SCHEMBL8868914 | 0.82 | HTR1D (0.85) | KMT2AHTR1DHTR1BHTR1AHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5637593-A | MIGRAINE; HYPOTENSIVE AGENTS | SMITHKLINE BEECHAM PLC (GB) | 1997-06-10 | — | — | US | disclosed |