Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 4/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.44 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.37 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.36 |
| ▸ | GPR183 | P32249 | 1/20 | 0.36 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.36 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.36 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.36 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL10505244 | 0.97 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL5088567 | 0.97 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL6257335 | 0.97 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL10697234 | 0.97 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL1728546 | 0.97 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL6258453 | 0.97 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL19329912 | 0.97 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL10696126 | 0.97 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL3842068 | 0.97 | FDPS (0.44) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL10693787 | 0.97 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0268261-A1 | Process for producing 1-hydrocarbyl mercaptans | PHILLIPS PETROLEUM COMPANY (US) | 1988-05-25 | — | — | EP | disclosed |