Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 4/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 4/20 | 0.43 |
| ▸ | DNM1 | Q05193 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 2/20 | 0.36 |
| ▸ | SGPL1 | O95470 | 1/20 | 0.35 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | GPR183 | P32249 | 1/20 | 0.35 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.35 |
| ▸ | CERS2 | Q96G23 | 1/20 | 0.35 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.35 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346990 | 0.97 | FDPS (0.46) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL10694081 | 0.97 | FDPS (0.46) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL6257335 | 0.94 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL5088567 | 0.94 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL19329912 | 0.94 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL10697234 | 0.94 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL10696126 | 0.94 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL1728546 | 0.94 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL10693787 | 0.94 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB | |
| Bromide SCHEMBL6258453 | 0.94 | SMPD1 (0.48) | FDPSSMPD1DNM1TSHRTHRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023159094-A2 | PROCESS OF MAKING 3α-HYDROXY-3β-METHOXYMETHYL-21-(1'- IMIDAZOLYL)-5α-PREGNAN-20-ONE | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-08-24 | — | — | WO | claimed |
| JP-55066531-A | — | — | None | — | — | JP | disclosed |
| WO-2024004508-A1 | METHOD FOR PRODUCING POLYSACCHARIDE FIBER | 旭化成株式会社 | 2024-01-04 | — | — | WO | disclosed |
| WO-2023159094-A2 | PROCESS OF MAKING 3α-HYDROXY-3β-METHOXYMETHYL-21-(1'- IMIDAZOLYL)-5α-PREGNAN-20-ONE | PRAXIS PRECISION MEDICINES, INC. (US) | 2023-08-24 | — | — | WO | disclosed |
| CN-112679498-B | Quaternary ammonium sulfonate compound and preparation method and application thereof | 北京耀诚惠仁科技有限公司 | 2022-11-29 | — | — | CN | disclosed |
| CN-112679498-A | Sulfonic acid quaternary ammonium salt compound and preparation method and application thereof | 北京耀诚惠仁科技有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-111116587-A | Preparation method of avibactam intermediate compound | 北京耀诚惠仁科技有限公司 | 2020-05-08 | — | — | CN | disclosed |
| EP-1682609-B1 | METHOD OF MODIFYING A FLUOROPOLYMER AND ARTICLES THEREBY | 3M INNOVATIVE PROPERTIES CO (US) | 2015-03-11 | — | — | EP | disclosed |
| EP-2014703-B1 | Process of preparing a composite article | 3M INNOVATIVE PROPERTIES CO (US) | 2009-12-09 | — | — | EP | disclosed |
| EP-2014703-A1 | Method of modifying a fluoropolymer and articles thereby | 3M Innovative Properties Company (US) | 2009-01-14 | — | — | EP | disclosed |
| US-20060029812-A1 | Method of modifying a fluoropolymer and articles thereby | 3M INNOVATIVE PROPERTIES COMPANY | 2006-02-09 | — | — | US | disclosed |
| US-6986947-B2 | Method of modifying a fluoropolymer and articles thereby | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2006-01-17 | — | — | US | disclosed |
| WO-2005037902-A1 | METHOD OF MODIFYING A FLUOROPOLYMER AND ARTICLES THEREBY | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2005-04-28 | — | — | WO | disclosed |
| US-20050080212-A1 | Method of modifying a fluoropolymer and articles thereby | 3M INNOVATIVE PROPERTIES COMPANY | 2005-04-14 | — | — | US | disclosed |
| WO-2004080583-A2 | PROCESS FOR THE PREPARATION OF threo-METHYLPHENIDATE HYDROCHLORIDE | ISP INVESTMENTS INC. (US) | 2004-09-23 | — | — | WO | disclosed |
| US-20040176412-A1 | Process for the preparation of threo-methylphenidate hydrochloride | ISP INVESTMENTS INC. | 2004-09-09 | — | — | US | disclosed |
| EP-0268261-A1 | Process for producing 1-hydrocarbyl mercaptans | PHILLIPS PETROLEUM COMPANY (US) | 1988-05-25 | — | — | EP | disclosed |
| US-4267317-A | CONCURRENT ETHERIFICATION AND DEHYDROGENATION OF A PHENOL BY REACTING WITH A 1-CARBOXY-3-HALOALKANE USING AN ALKALI METAL COMPOUND AND A SPECIAL SOLVENT | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 1981-05-12 | — | — | US | disclosed |
| US-4254262-A | IN THE PRESENCE OF A QUATERNARY AMMONIUM OR PHOSPHONIUM SALT | IHARA CHEMICAL INDUSTRY CO., LTD. (JP) | 1981-03-03 | — | — | US | disclosed |
| JP-S5566531-A | PREPARATION OF PHENOXYALKENE DERIVATIVE | IHARA CHEM IND CO LTD | 1980-05-20 | — | — | JP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040176412-A1 | Process for the preparation of threo-methylphenidate hydrochloride | COMT, METTL3, SLC6A3 | FDPS 4660/4885SMPD1 3187/4885DNM1 2447/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.