Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MPL | P40238 | 2/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CBFB | Q13951 | 1/20 | 0.35 |
| ▸ | SCN10A | Q9Y5Y9 | 3/20 | 0.34 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10694085 | 0.92 | METAP2 (0.31) | METAP2HDAC6MPL | |
| SCHEMBL10576865 | 0.86 | HDAC6 (0.43) | METAP2HDAC6DGAT1KCNH2NPBWR1 | |
| SCHEMBL10574922 | 0.82 | HDAC6 (0.43) | HDAC6DGAT1KCNH2NPBWR1TP53 | |
| SCHEMBL10574859 | 0.82 | METAP2 (0.42) | METAP2HDAC6DGAT1KCNH2CBFB | |
| SCHEMBL10575761 | 0.82 | METAP2 (0.43) | METAP2HDAC6MPLDGAT1KCNH2 | |
| SCHEMBL10577338 | 0.82 | DGAT1 (0.57) | HDAC6DGAT1KCNH2NPBWR1TP53 | |
| SCHEMBL10575299 | 0.81 | METAP2 (0.40) | METAP2HDAC6MPLKCNH2CBFB | |
| SCHEMBL10694817 | 0.81 | SCN10A (0.40) | METAP2HDAC6DGAT1KCNH2SCN10A | |
| SCHEMBL10575346 | 0.81 | METAP2 (0.41) | METAP2HDAC6MPLCBFBNPBWR1 | |
| SCHEMBL10695359 | 0.80 | METAP2 (0.66) | METAP2CBFBTP53MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0266558-A2 | 5-Alkylbenzimidazoles, process for their preparation and medicaments containing them | Roche Diagnostics GmbH (DE) | 1988-05-11 | — | — | EP | disclosed |