SCHEMBL10694539

SCHEMBL10694539

CC(C)(C)c1ccc(C[Si](C)(C)CN2CCCC2)cc1

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
SIGMAR1 Q99720 7/20 0.53
KDM4E B2RXH2 2/20 0.45
KCNH2 Q12809 1/20 0.45
HRH3 Q9Y5N1 3/20 0.43
TEAD1 P28347 2/20 0.43
ALDH1A1 P00352 1/20 0.42
TMEM97 Q5BJF2 3/20 0.40
CYP2C9 P11712 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10695755 0.98 SIGMAR1 (0.55) SIGMAR1KDM4EKCNH2HRH3TEAD1
SCHEMBL7333053 0.80 SIGMAR1 (0.45) SIGMAR1KDM4EHRH3ALDH1A1
Hydrochloric Acid SCHEMBL7339087 0.80 HRH3 (0.51) HRH3TEAD1ALDH1A1
SCHEMBL10212101 0.79 HRH3 (0.65) SIGMAR1KDM4EKCNH2HRH3ALDH1A1
SCHEMBL10692606 0.79 SIGMAR1 (0.60) SIGMAR1KCNH2TEAD1ALDH1A1
SCHEMBL10692601 0.79 SIGMAR1 (0.60) SIGMAR1KCNH2TEAD1ALDH1A1
SCHEMBL10693219 0.79 HRH3 (0.46) KDM4EHRH3ALDH1A1
Hydrochloric Acid SCHEMBL7336348 0.79 HRH3 (0.46) SIGMAR1KDM4EKCNH2HRH3ALDH1A1
Hydrochloric Acid SCHEMBL7336557 0.79 KDM4E (0.58) SIGMAR1KDM4EHRH3ALDH1A1TMEM97
Hydrochloric Acid SCHEMBL7338771 0.79 SIGMAR1 (0.44) SIGMAR1KDM4EHRH3ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4762826-A FUNGICIDES FOR PLANTS CIBA-GEIGY CORPORATION (US) 1988-08-09 US disclosed